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A vaccine for cocaine addiction?
A new vaccine could immunize drug addicts from the high-inducing effects of specific narcotics
 
In lab trials on mice, the effects of the cocaine-addiction vaccine lasted at least 13 weeks.
In lab trials on mice, the effects of the cocaine-addiction vaccine lasted at least 13 weeks.
Corbis

Scientists have discovered a vaccine that can theoretically immunize a drug addict against a high from cocaine, heroin, or other drugs. In tests on lab mice, researchers at Weill Cornell Medical College in New York were able to prevent injected cocaine from reaching the rodents' brains.

So how does this vaccine work?
To create the vaccine, scientists grafted a molecule very similar to cocaine onto a part of the common cold virus. They then injected the modified virus into the mice, whose bodies responded by producing antibodies. When the vaccinated mice were later injected with cocaine, their immune systems again reacted and the antibodies neutralized the cocaine. The result: The coked-up mice did not get high. The effects of a single vaccination lasted for at least 13 weeks.

Is this the first time something like this has been tried?
No, but the researchers behind the tests say it is the first single vaccination to successfully produce such results. "While other attempts at producing immunity against cocaine have been tried, this is the first that will likely not require multiple, expensive infusions, and that can move quickly into human trials," says Ronald Crystal, professor of genetic medicine at Weill Cornell Medical College.

Could this really help addicts?
Yes, says Crystal. "The vaccine may help them kick the habit because if they use cocaine, an immune response will destroy the drug before it reaches the brain's pleasure center." Not so fast, counters Jeffrey Kluger at Time. This vaccine is "not a panacea." If cocaine fails to give the desired buzz, then drug users will move onto other substances. Addiction is psychological, as well as physical, and "addicts are nothing if not resourceful."

Sources: Molecular Therapy, LiveScience, Time

 

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