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Oprah's best interviews: A slideshow
With her last show set for Wednesday, here's a look back at some of the best moments from the Queen of Talk's 25 years on the air
 
Oprah Winfrey Facebook/Oprah

The end is near. After 25 years, The Oprah Winfrey Show will air its final episode this Wednesday, leading fans and commentators to reflect on Oprah's most memorable (and, in some cases, indelible) guests over the years. Here, 10 highlights:

 

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