A cargo train derailed Tuesday in a Baltimore suburb after colliding with a tractor-trailer, resulting in a huge explosion that shook buildings and shut down a nearby highway.

Authorities said the train struck the tractor-trailer around 2 pm, flipping several cars off the tracks. The severity and extent of injuries related to the accident were not immediately clear, though officials said the derailment took place in a sparsely populated industrial area. The two passengers aboard the train were reportedly uninjured, and the truck driver was said to be in serious but stable condition.

Baltimore police urged anyone in the area to consider evacuating as a precaution.

The warning came as amateur videos appearing to show the huge explosion and resulting inferno began to trickle out (WARNING: Video contains some coarse language):

Twitter users have posted incredible images of the wrecked train engulfed in flames.

Baltimore's fire chief said 15 cars had jumped the tracks. He added that emergency responders were containing the blaze and letting the fire burn itself out until they can determine what the train was carrying.