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Older fathers and the autism surge

The older a man is when he becomes a father, the more likely he is to pass on genetic mutations that can cause autism, schizophrenia, and other disorders in his children, a new study has found. The finding suggests that autism rates are rising in part because men are waiting longer to have children. Researchers analyzed the genetic makeup of 78 Icelandic families in which offspring had been diagnosed as having autism or schizophrenia. They found that those disorders arose primarily from random mutations in the DNA provided by the father’s sperm. Women produce their eggs early in life, so over time, there is no significant increase in mutations. But men constantly produce new sperm, and the process of genetic copying becomes more imprecise as they age. A 20-year-old father was found to contribute an average of 25 new genetic mutations to his child; by the age of 40 that average had risen to 65. Only a fraction of those mutations lead to mental disorders. Still, University of Iceland geneticist Kari Stefansson tells the Los Angeles Times, the trend toward later fatherhood is “very likely to have made meaningful contributions to increased diagnoses of autism in our society.” He attributes 15 to 30 percent of autism cases to genetic mutations from older fathers. Even so, the risk of a man in his 40s fathering a child with genetic disorders remains relatively low at 2 percent.

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