Bluffton. This three-bedroom, custom-built home sits along the 12th fairway of the May River Golf Course. The house has a cathedral-style living room, wood floors, and a master suite with a fireplace, a spa bathroom, and a balcony.

The property includes an additional apartment above the garage as well as a freestanding one-bedroom guesthouse. $1,895,000. Palmetto Bluff, (800) 501-7405.

Columbia. This lakefront house on a 1.72-acre wooded lot is only 15 minutes from the capital center. The home boasts four en suite bedrooms, a spiral staircase, a large screened-in porch, and a beamed cathedral ceiling in the main living space.

Every room provides a view of the water. $549,900. Georgianna Siokos-Evans, Coldwell Banker/ United, (803) 238-1595.

Bluffton. This four-bedroom waterfront home lies within a boating and golf community overlooking the Colleton River. The house features a curved-glass staircase, an elevator, a mahogany pub room, and a master suite with a sitting room and a fireplace.

Property amenities include a pool and a spa, as well as a deepwater dock with two boatlifts. $2,990,000. Linda Rudd, Engle & Völkers, (843) 816-5522.

Charleston. Built circa 1735, the Thomas Rose House is listed on the National Register of Historic Places. Original details include wood paneling, decorative mantelpieces, and a drawing room.

The double-lot property features a rear piazza, a Loutrel Briggs–designed garden, and the original outbuildings. $4,800,000. Helen Geer, William Means Real Estate, (843) 577-6651.

Isle of Palms. This five-bedroom home was built as the personal residence for an area builder. The 4,960-square-foot house includes heart pine and coral floors, iron railings, a gourmet kitchen, and a media room.

The waterfront property features a pool, a fire pit, a grilling area, and a deepwater dock on the Intracoastal Waterway. $3,450,000. Champ Smith, S.C. Places, (843) 224-1811.

Hartsville. Set on 12 acres, this four-bedroom home was built in 1968. The house has a formal dining room, a large open kitchen, two fireplaces, and a sunroom with open beams. The master bedroom suite has dual closets and sinks as well as a large tub and a separate walk-in shower.

The property includes a patio and a workshop. $575,000. Deborah Griggs, Better Homes and Gardens Real Estate, (843) 616-2687.

River Hills. Associates of Frank Lloyd Wright constructed this three-bedroom home in 1989. The Colonnade typifies organic architecture by incorporating the building, furnishings, and environment into one entity.

Interior details include built-in furnishings and brick and mahogany walls and ceilings throughout. $374,900. Hanes Walker, Premier/Sotheby's International Realty, (704) 366-2830.

**Want more? Check out the 6 stunning homes in New Orleans**