Health & Science

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Programming yourself to be fat

Eating lots of cheeseburgers, fries, and sugary snacks makes people gain weight—but not, new research shows, just because these foods are so high in calories. A high-fat, high-sugar diet, say Washington University scientists, changes the balance of bacteria in the gut, and effectively “programs’’ people’s digestive systems to make them fat. The human intestinal tract has two main types of bacteria that help us digest food: Firmicutes and Bacteroidetes. Research has shown that people—and mice—with a high percentage of Firmicutes in their intestines tend to be fat, because these bacteria are very efficient at converting food into calories that the body then absorbs. Those with a preponderance of the less-efficient Bacteroidetes remain relatively lean. Researchers found that when they transferred intestinal bacteria from obese mice into the guts of previously microbe-free mice, the mice rapidly gained weight. When both types of bacteria were inserted into skinny mice, they stayed lean—until they began eating a diet high in fat and sugars. Then the count of “lean’’ bacteria dwindled, while the “fat’’ bacteria proliferated and took over the gut. As a result, the once-skinny mice bulked up. The results, researcher Jeffrey Gordon tells the Los Angeles Times, suggest that our resident microbes

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