The process of evolution usually takes thousands, millions or even billions of years. But researchers have found a way to condense it into a matter of minutes using a method called 'directed evolution,' which allows proteins to rapidly advance. It may be used for a variety of treatments and medical advancements in the future.
Directed evolution is the "process of rapidly evolving proteins, introducing beneficial mutations and selecting advantageous variants," said Popular Mechanics. The "hyper-evolved proteins can be used in a wide variety of potential cancer and neurodegenerative therapies." While this process has been explored for years, scientists from Scripps Research Institute recently created a system called T7-ORACLE that can speed up evolution by an unprecedented 100,000 years and introduce mutations in minutes, according to a study published in the journal Science.
Since directed evolution "can force these molecules to evolve in the lab within a much-shortened time scale," there are many promising applications for the technology, said The Scientist. It could be an "important tool for developing new medicines," as well as "give scientists a better understanding of how antibiotic resistance builds up over time," said Popular Mechanics. Protein evolution can also be used to switch diseases off, as well as for diagnostic purposes.
And the applications are not merely medical; the technology could "lead to enzymes with helpful abilities such as breaking down the plastic in soda bottles that would otherwise persist in the environment," said Caltech Magazine. "What matters is that we can now evolve virtually any protein, like cancer drug targets and therapeutic enzymes, in days instead of months," said Christian Diercks, a co-senior author of the study. |