Health & Science

A new way to block HIV; A possible alternative to Viagra; Doodling for better concentration; The porn paradox; The value of interruptions

A new way to block HIV

Efforts to find a vaccine to prevent AIDS have thus far failed. But scientists have high hopes that a common antimicrobial gel could protect millions of women from the disease. A new University of Minnesota study involving monkeys found that the antimicrobial agent, called glycerol monolaurate, or GML, might greatly reduce a woman’s risk of being infected, especially in Africa, where women are often afraid to use condoms because of their partners’ objections. It can also protect men who have sex with men. After a woman has sex with an HIV-infected partner, her immune-response cells rush to the blood vessels in the vagina to attack the invading virus. But instead of protecting her, this attack squad of infection-fighting cells actually makes the female more vulnerable to contracting HIV because the virus is designed to penetrate immune cells and turn them into virus-making factories. The gel appears to protect the body from infection by suppressing the immune response—in effect, by telling the body to ignore the virus. “You would think we should induce the innate immune response,” immunologist Ashley Haase, author of the study, tells Nature. “But it turns out these viruses have not only learned to live with that immune response, they relish it.” In his monkey trials, vaginal application of the gel before sex blocked four out of five infections by the simian version of HIV.

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