To converts sharing tips online, microdosing Ozempic or other semaglutide-based drugs is crafty way to lose pounds without enduring "eggy burps," constipation and other suboptimal side effects of the weight-loss drug, said Harriet Walker at The Times. But some experts are warning against this trend.
'Massive spikes' in interest A growing number of influencers and other users are microdosing Ozempic, taking a tiny amount, as a weight-loss "hack" following "horror stories" about side effects of the standard dose, including "nausea, vomiting" and "intense constipation," said The New York Times. Google Trends keyword analysis reveals "massive spikes" in interest in the practice over the past year, said science news site Futurism.
Placebo effect "I microdosed a similar weight-loss drug, Mounjaro," said Walker. "After a week, I had shifted half a stone that I have been trying to lose for as long as I can remember." Jeans that "I hadn't been able to sit down in for a year fit again," and my sciatic pain "is gone."
But users "don't typically get weight loss if we go to such a low dose," Mir Ali, the medical director of MemorialCare Surgical Weight Loss Center in California, said to Women's Health. Some experts believe those who do lose weight by microdosing, essentially taking an amount that's subtherapeutic (less than the amount required for treatment), may be "super responders" who are especially sensitive to the effects of the drug, said The New York Times. And the loss may also be the result of a placebo effect that encourages them to make other changes to their lifestyle.
Getting the dose right "requires complicated maths and conversions," Dr. Alexandra Sowa, the author of "The Ozempic Revolution," said to Women's Health. Prolonged use of tiny amounts of medication also increases the risk of consuming it after the use-by date. |