by Tom Zeller Jr.
“Roughly 40% of the global population, or 3.1 billion people, suffer some kind of headache disorder,” said Brandy Schillace in The Wall Street Journal. Yet because the source is unknown and invisible, the pain is often brushed off, “or worse, considered imaginary.” Tom Zeller Jr.’s new book about migraines and other debilitating headaches can’t solve the mystery of their cause. But he provides “ample and vivid evidence of the all-consuming pain that headache sufferers endure” and, using a tour through medical history and his own experiences of excruciating cluster headaches, argues powerfully that researchers and their funders must direct more attention to relieving the afflicted.
“Why are migraines such a common part of human experience?” asked physician Jerome Groopman in The New Yorker. Other mammals don’t seem to suffer chronic headaches, which suggests that they’re produced in the interaction of the most primitive and the more advanced parts of the brain. Headaches were taken seriously by the medical profession up through the 19th century. But even though 40 million of today’s Americans suffer from migraines, costing the economy as much as $1 trillion a year, research into the cause has been feeble ever since, leaving doctors divided about whether the root trouble lies in abnormal functioning of blood vessels or in an abnormal flux of ions in the brain, mimicking epilepsy. Like many other migraine sufferers, I now use several medications to manage the challenge, after chasing a medical solution for years. “Reading Zeller’s book, I was reminded that there is a kind of uneasy fellowship in this condition—a vast, involuntary community of people mapping out their lives between attacks, haunted by uncertainty but sustained in part by accounts like his.”
The reasons that so little progress has been made are “highly contested,” said Laura Miller in Slate. Migraines afflict three times as many women as men, suggesting that some blame lies in gender bias. But cluster headaches, which are more painful but far rarer, afflict mostly men. Fortunately, there’s been progress in the past 35 years on treatment options, including the one I depend on, sumatriptan, which stimulates serotonin receptors. “While the medical explanations in The Headache occasionally made my eyes glaze over,” Zeller’s accounts of feuds among headache researchers and potential federal funders “present a delectable blend of dish and substance.” And such fights matter. After all, “for millions of people, headaches are a literal torment.” |