While we may think of mucus as merely the slimy substance that clogs our nose and gets blown into a tissue, it's so much more. It lines several body organs, acting as a first line of defense against foreign invaders, as well as aiding essential body functions like digestion and illness prevention. And now scientists are taking inspiration from mucus for new disease-fighting treatments.
What is it made of? It's more than 95% water, but its "key building blocks are mucins, which are long proteins decorated with complex sugars that make them look like bottlebrushes," said The New York Times. These mucins "attract and retain water, giving mucus its slippery, gel-like consistency," said New Scientist. This allows mucus to keep the passages wet. "Mucins crosslink with themselves and other compounds, creating a meshlike configuration," and the "more mucins in mucus, the denser this network becomes."
What can it do? Mucus is a "masterpiece of biological engineering in my mind," said Katharina Ribbeck, a professor of biological engineering at MIT, to the Times. It serves several purposes, from protecting us from pathogens to helping with digestion.
The goopy substance protects the human body by being both a physical barrier and chemical barrier. It works by "shielding the body from unwanted objects and molecules," as well as "actively interacting with foreign materials," said New Scientist. Mucus is "almost like a bouncer at an exclusive nightclub, deciding who gets through."
It also "lines all our wet epithelial surfaces," said Rebecca Carrier, a chemical engineering professor at Northeastern University, to Northeastern Global News. This includes the nose, eyes, ears, throat, lungs, stomach, and urological and genital tracts. Its composition and consistency can vary as needed. For example, "human cervical mucus becomes thinner and more watery during ovulation, enabling sperm to penetrate it more easily," said New Scientist. It might even "respond to our body's internal clocks."
How can it help further medicine? Researching how mucus works could open exciting possibilities. Mucins contain sugar molecules called glycans that can uniquely fight pathogens. Rather than killing them, the glycans are a food source for the bacteria. Treating the microbes this way "seems to tame them, rendering them less harmful," said Ribbeck to New Scientist. Using glycans or "molecules mimicking them" could be an "alternative to antibiotics or immunotherapies." |