Scientists have taken a "decisive step" toward creating universal donor blood by identifying a "cocktail" of bacterial enzymes that effectively removes antigens, Technical University of Denmark (DTU) said. Researchers at DTU and Lund University in Sweden said the discovery could significantly reduce the risk of a negative reaction.
About 50% of people naturally have type O, or "universal," blood, but those with type A, type B and the rarer type AB blood can currently only give and receive blood within their own group. This is because antigens, the chains of sugars attached to the body's red blood cells, take on different forms in type A and type B blood and can "trigger life-threatening immune reactions when transfused into non-matched recipients," DTU said in a press release.
Scientists have "experimented with enzymes" to remove antigens from blood for decades, said The Economist. But the new combination appears to be effective on "lengthened antigen sugar chains, called extensions, that are not targeted by current enzymes."
The study's lead author, Professor Maher Abou Hachem, said the team was "close" to producing universal blood from group B donors, while more work was needed on the "more complex" group A blood.
The ability to convert blood from any donor into a universal type would "markedly reduce the logistics and costs currently associated with storing four different blood types," said DTU. Every drop counts; blood banks in the U.S. and U.K. have warned of dwindling supplies, and "aging populations are expected to increase the demand for blood yet further," said The Economist. |