The "pharaoh's curse" fungus may sound ominous, but scientists have discovered that certain molecules it contains stop the proliferation of cancer cells as effectively as FDA-approved drug treatments. The fungus, officially named Aspergillus flavus, can be used to fight leukemia, according to a study published in the journal Nature Chemical Biology.
The fungus is "linked to the deaths of several archeologists who opened ancient tombs" around the world, including the "famous discovery of the tomb of Tutankhamun in the 1920s," said Popular Mechanics. At the time, many believed the deaths to be the result of an ancient curse rather than fungal inhalation.
Aspergillus flavus, commonly found in soil, can infect a wide range of key agricultural crops. Exposure to it can lead to lung infections, but it also contains peptides that can fight cancer when modified.
Four molecules that researchers were able to isolate from A. flavus "demonstrated medical potential when mixed together with human cancer cells," said Popular Science. Two of the four molecules, which they named asperigimycins, "had potent effects against leukemia cells."
Asperigimycins are part of a class of molecules called ribosomally synthesized and post-translationally modified peptides, or RiPPs. A number of them have been found in bacteria, but they are "rare in fungi and notoriously hard to study," said Wired. Still, "almost all of them have strong bioactivity," study co-author Qiuyue Nie said in a statement.
Fungi have long been a source of medicine, perhaps most importantly for the antibiotic penicillin. This research implies there's more where that came from. |