Have you ever woken up in the morning and suddenly felt old? There might be a good reason. Rather than aging gradually on a linear timescale, we seem to have significant "bursts" of getting old during our adult years, said National Geographic.
These bursts usually happen in our mid-40s and early 60s, according to a researchers at Stanford University who tracked thousands of different molecules in people aged 25 to 75. Up to 81% of the molecules don't change continuously but instead transform significantly around certain ages, the researchers found.
It's already known that sudden chemical modifications to DNA occur in mice in early to mid-life, and again in mid to late life, thanks to a study last year by German researchers. And there are "significant jumps" in concentrations of blood plasma proteins associated with aging in the fourth, seventh and eighth decades of human life, a 2019 analysis found.
All this "sudden aging" can come with an "acceleration in muscle wastage and skin decline," said New Scientist, along with an inability to metabolize alcohol, a swift dwindling of immune cells, and substantial increases in the risk of cardiovascular disease and dying.
These "provocative" findings seem to "fly in the face" of current models of aging, said David Sinclair, a molecular geneticist, longevity researcher and professor at Harvard Medical School.
But, with other studies suggesting people often experience a "midlife crisis" in their late 30s and early 40s or a "late-life crisis" in their late 50s and early 60s, said Sinclair, it's possible that "associated psychological and lifestyle changes may be responsible for these changes in aging" and not our "inherent biology." |