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May 4, 2014
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Two studies published on Sunday show that blood from young mice reversed aging in old mice, rejuvenating both their muscles and their brains, The New York Times reports.

Dr. Saul Villeda at the University of California, San Francisco, and his colleagues discovered that after young mice and old mice were stitched together at their flanks and their blood was flowing through each other, the old mice formed several new neurons in the hippocampus region of the brain, an important area for imprinting memories. The scientists also removed cells and platelets from the blood of young mice and injected the remaining plasma into old mice, which helped the older rodents perform better on memory tests.

Over at Harvard University, Dr. Amy J. Wagers and her team found that when old mice were joined together with young mice, more blood vessels grew in the brain of the old mice, leading to the creation of more neurons that gave the old mice a better sense of smell. During an earlier study, Wagers and her colleagues had discovered that GDF11, a protein, was plentiful in young mice and scarce in old mice, and could rejuvenate heart tissue when injected into older mice.

This time around, Wagers and her colleagues injected GDF11 into the old mice (not joined to younger mice) and found that it also spurred the growth of blood vessels and neurons in the brain, as well as — in a separate new study — stem cells in the aging muscles, increasing the strength and endurance of older mice.

Taken together, the separate research could eventually lead to treatments for human heart disease and degenerative brain disorders like Alzheimer's, among other Fountain of Youth remedies. "There's no conflict between the groups, which is heartening," Dr. Richard M. Ransohoff, director of the Neuroinflammation Research Center at the Cleveland Clinic, told The New York Times.

The idea of being able to rejuvenate body parts this way is exciting, but scientists also warn that stem cells could multiply uncontrollably, leading to cancer. Villeda's team published its findings in the journal Nature Medicine, while Wagers' studies came out in Science. Catherine Garcia

12:50 p.m. ET

Senate Minority Whip Dick Durbin (D-Ill.) on Sunday roundly rejected President Trump's proposal that the Senate GOP go "nuclear" to end the government shutdown without Democrat's help. "I can tell you that would be the end of the Senate as it was originally devised and created going back to our founding fathers," Durbin said in an interview on ABC. "We have to acknowledge our respect for the minority, and that is what the Senate tries to do in its composition and in its procedure."

When Democrats controlled the Senate in years past, Durbin did not seem to hold this view. In 2014, for example, he defended Democrats' 2013 decision to invoke the nuclear option with judicial nominees by arguing Democrats had "no choice" because of Republican obstructionism.

But this time, Durbin has Senate Majority Leader Mitch McConnell (R-Ky.) on his side; McConnell said through a representative Sunday he "opposes changing the rules on legislation." Watch an excerpt of Durbin's comments on ABC below. Bonnie Kristian

12:32 p.m. ET

The White House public comment line is not accepting calls during the government shutdown, and the voicemail message has been updated to blame this change on Democrats.

"Thank you for calling the White House," the message says. "Unfortunately, we cannot answer your call today because congressional Democrats are holding government funding, including funding for our troops and other national security priorities, hostage to an unrelated immigration debate."

Callers are encouraged to contact the White House online instead, because apparently the internet is better suited to weathering the shutdown storm. Bonnie Kristian

12:19 p.m. ET

In an appearance on CNN's State of the Union Sunday, Sen. Rand Paul (R-Ky.) went after both parties for their conduct during the government shutdown and throughout the bitterly partisan negotiations that produced it. "I think the blame game is ridiculous on both sides," he said. "I think the American people see through it."

Paul voted against his own party's proposal for a short-term funding bill on Friday, and he argues the GOP could secure a spending deal immediately if Republican leadership would guarantee — and Democrats would accept — an "open process" of votes on immigration policy, centrally including the Deferred Action for Childhood Arrivals (DACA) program.

"The DACA issue has been held hostage to people on the left who want their perfect immigration bill or nothing, and people on the right who want nothing," Paul said on CNN. "And so, really, I'd say, let's vote on it. Let's just put it forward and vote on it. And I think the impasse could end today if Republicans would promise just to have a week of immigration votes, have a conclusion, let us all put forward amendments. I think the American people would like to see us hash out our differences through amendments and votes."

Watch a clip of Paul's interview below. Bonnie Kristian

11:58 a.m. ET

House Speaker Paul Ryan (R-Wis.) argued on CBS Sunday that blame for the government shutdown rests entirely with Senate Democrats. "We're waiting for the Senate Democrats to open the government back up," Ryan told host John Dickerson.

"This is solely done by the Senate Democrats. It's absolutely meaningless," he continued, accusing Democrats of posturing that undercuts their own political aims. "What's so baffling about this is we [Republicans] were negotiating in good faith on [Deferred Action for Childhood Arrivals (DACA)]," Ryan said. "We actually want to solve this problem. So it's not as if we were saying, 'No way, no how, no discussions.'"

Ryan made similar remarks on the House floor Saturday, pledging the GOP is "willing to work together in good faith on immigration" policy. "You should not have to go through this uncertainty," he said to federal workers. "You deserve so much better than this needless shutdown. And we hope that it will end very soon."

Watch an excerpt of Ryan's CBS interview below. Bonnie Kristian

11:30 a.m. ET

President Trump tweeted Sunday that the GOP should change Senate rules to pass a funding bill to end the government shutdown without Democrats' help. Senate Majority Leader Mitch McConnell (R-Ky.), however, has never shown enthusiasm for this "nuclear option," and he indicated through a representative Sunday he does not support Trump's idea.

"The Republican Conference opposes changing the rules on legislation," McConnell's statement said. That means it is unlikely a spending deal will be passed with a simple majority of 51 votes (rather than the present 60), as Trump hopes.

That intra-party opposition did not prevent the White House from continuing to advocate the change. Office of Management and Budget Director Mick Mulvaney argued on CNN's State of the Union Sunday that Trump's proposal "responds to this constant criticism we hear" that Republicans should be able to fund the government because they control both the executive and legislative branches.

"The answer is, as you've just laid out, it takes 60 votes in the Senate," Mulvaney said. "We cannot open the government without Senate Democrat support. We don't have that support, which is why we are where we are." Watch his comments in context below. Bonnie Kristian

10:31 a.m. ET

Special Counsel Robert Mueller, implausibly but effectively played by a giggly Kate McKinnon in shoulder pads and facial prosthetics, visited Saturday Night Live's Weekend Update in a jovial mood to discuss his Russia investigation with host Colin Jost.

McKinnon's Mueller coyly insisted he could not discuss his ongoing probe into Russian election meddling and alleged Trump campaign collusion, but he was more than willing to offer a few hints of how well it's going. "Colin, you gotta understand, the guy didn't leave me a trail of breadcrumbs," Mueller said of President Trump. "He left me full loaves — fresh, seven-grain loaves straight from Panera Bread. I'm having a blast, man."

Watch the full skit below. Bonnie Kristian

10:16 a.m. ET
Jacquelyn Martin/The Associated Press

House Speaker Paul Ryan (R-Wis.) removed Rep. Patrick Meehan (R-Pa.) from the House Ethics Committee on Saturday in response to a New York Times report that Meehan used tax dollars to settle a case with a former female aide who accused him of sexual misconduct. Ryan also directed Meehan to repay the unknown amount out of his own pocket, and to submit to an ethics investigation.

The Times reported that Meehan, who is married, expressed romantic interest in the aide with a handwritten letter and "grew hostile" when she rebuffed him. After she left her position because of the harassment, the report says, the aide "reached a confidential agreement" with Meehan, including a settlement paid out of his congressional account.

Meehan has denied any inappropriate behavior. His office said in a statement he "has always treated his colleagues, male and female, with the utmost respect and professionalism." Bonnie Kristian

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