Scientists are putting the pedal to the metal in the race to develop new antibiotics. Metal-based drugs could open up a new world of medicine, especially as antimicrobial resistance is growing. Researchers have also found a way to create and test these metal compounds much faster than before through the use of robots.
Robotic chemistry can be used to produce and trial metal-based antibiotics, according to a study published in the journal Nature Communications. Most modern antibiotics are organic or carbon-based and tend to interact with bacteria in predictable ways. However, metal-containing compounds have a unique geometry that “allows them to interact with bacteria in completely different ways, potentially overcoming the resistance mechanisms that defeat current drugs”, said a release about the study.
An iridium metal complex was specifically identified as a promising antibiotic drug. It “demonstrated high effectiveness against bacteria, including strains similar to the deadly MRSA (Methicillin-resistant Staphylococcus aureus), while displaying low toxicity to human cells”, said the release.
The findings come at a time when antibiotic resistance is becoming more of a danger. “The pipeline for new antibiotics has been running dry for decades,” Dr Angelo Frei, the lead author of the study, told Live Science.
Still, because bacteria evolve quickly, there is a risk of resistance developing to these compounds over time. The good news is that robotic chemistry can significantly speed up research. “The iridium compound we discovered is exciting, but the real breakthrough is the speed at which we found it,” said Frei. “This approach could be the key to avoiding a future where routine infections become fatal again.” The method could also be used beyond antibiotics to help further several other areas of biomedical research. |