The internet is rife with trends promising to optimize your body, and right now, peptides are the It drug. Available as injectables, intravenous infusions, pills and nasal sprays, these chains of amino acids are rumored to help with weight loss, anti-aging and rapid muscle repair. But government restrictions have led to an increase in gray-market sales.
New wonder drug? The human body naturally produces peptides. Researchers have known about some of them for decades, and “dozens have been turned into safe and effective drugs,” said The New Yorker. The hormone insulin, for example, “moves sugar from the bloodstream into cells” and is used to treat diabetes.
The drugs that are driving current wellness trends are part of a broad category of synthetic amino acids that includes “well-studied items like insulin and GLP-1 weight-loss drugs,” said Stat News. Unlike those two FDA-approved uses, however, the peptides being touted by some figures in the health sphere are part of a “thicket of newer drugs,” most of which have “comparatively little research” to support claims they can “treat injuries and chronic pain” or “boost energy.”
Off-label use of peptides was initially popular among bodybuilders, but in the “era of Make America Healthy Again,” peptides’ popularity has risen among the general public, said The New Yorker. Compounding pharmacies are experiencing soaring demand, and imports of gray-market peptides from China nearly doubled last year, said The New York Times. Influencers like “looksmaxxer” Clavicular and podcaster Joe Rogan, as well as Health Secretary Robert. F. Kennedy Jr., are among those singing their praises.
Kennedy and the gray market In 2023, during Biden’s administration, the FDA placed 14 peptides on a “do not compound” list due to “potential significant safety risks,” including immune reactions, pancreatitis and accelerated growth of cancerous cells. But in February, Kennedy said the FDA would make changes to make their use more acceptable.
A senior Health Department official confirmed that the FDA plans to move forward in allowing compounding pharmacies to produce the injectable peptides, said the Times. Lifting the restrictions would be done in an effort to curtail the use of “substandard” gray-market products, said Kennedy on Joe Rogan’s podcast.
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