A type of sea squirt discovered 20 years ago on an expedition to Antarctica was subsequently identified as a potential cancer therapy. The marine invertebrate contains a bacterium, Candidatus Synoicihabitans palmerolidicus, that can “produce the metabolite palmerolide A, which kills melanoma cells without causing too much harm to healthy human cells,” said Discover. Scientists have now conducted a second expedition to Antarctica to “better understand the compound and explore whether it could someday contribute to new therapies for patients battling melanoma,” the University of South Florida said in a news release.
Sea squirts, or ascidians, are “sac-like marine invertebrates that tend to live on sloped sea beds,” said the BBC. Those found in Antarctica have “evolved over millions of years to cope with the harsh conditions there, producing chemical defenses that can deter predators and disease.”
Researchers tested the sea squirt’s bacteria on melanoma cells in mice. “The good news is it didn’t kill the mice,” said expedition leader and adviser Bill Baker, a USF chemistry professor, to The Guardian. “It did kill their cancer, so we know it has the physiological properties to act like a drug.”
Most FDA-approved drugs originated in nature, and Antarctica could be a rich source of new possibilities. But while the sea squirt shows promise, the “pathway to producing a safe and effective anti-melanoma drug, with approval for use in humans, is long,” said The Guardian. It would “require a succession of strictly regulated and ever-expanding trials even after a drug was formulated.”
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