After 423 days in office, President Trump has gotten rid of more Cabinet officials (three, in Health and Human Services Secretary Tom Price, Homeland Security Secretary John Kelly, and Secretary of State Rex Tillerson) than most presidents lose in their first two years on the job. In fact, NPR reports, no other "elected first-term president in the past 100 years has had this much Cabinet turnover this early in his presidency."
Most presidents since Woodrow Wilson have replaced just one Cabinet member in the first 14 months, and several have kept the same Cabinet throughout that time. Only three — Warren G. Harding, Gerald Ford, and Ronald Reagan — have swapped more than two in the first two years of office, and Trump is easily on pace to exceed Reagan's four Cabinet departures in that span.
Kelly, for his part, was reassigned to be Trump's chief of staff. But if Trump continues swapping Cabinet secretaries at the current rate, Trump will replace 10 Cabinet members by the time his first term is complete. There are 16 members of the Cabinet, including the vice president.
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