Infecting yourself with internal parasites doesn’t sound like the best way to feel better, but scientists have “engineered” the genes of hookworms to deliver medicine – and “it’s just crazy enough to work”, according to ZME Science.
US researchers have genetically modified hookworms to produce and secrete specific antibodies. This is a “first step” towards creating “living pharmaceutical factories” that can release therapeutic proteins “directly inside the host”, they said in their study, published in Nature Communications.
The hookworm has “spent millions of years perfecting how to assure long-term survival inside a human host, and how to get molecules out of its body and into ours”, said senior study author Dr Makedonka Mitreva, from Washington University in St Louis, on science news release site EurekAlert!
Mitreva and her team used CRISPR gene-editing technology to insert into a hookworm egg genome “a gene coding for an antibody known to counteract” the pufferfish poison tetrodotoxin, a lethal, weaponisable neurotoxin with no known commercial antidote. They then infected hamsters with the modified parasites, and samples taken later showed that the animals had antibodies to tetrodotoxin circulating in their blood.
“It was like the perfect moment,” Mitreva told R&D World. Now “we can start embarking on hookworms being a two-in-one platform” because we’ve shown that they “can not only deliver a drug, but produce that drug and deliver it”.
This is an “exciting” approach that “paves the way for all sorts of injection-free biologic drug delivery”, added ZME Science. It’s “tantalising” to think that “engineered hookworms could one day” be our “internal allies, providing continuous therapeutic benefits while living safely within a human host”.
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