Colossal Biosciences claims to have reached several milestones in its "Jurassic Park"-like ambition to bring several extinct species back to life, helping it capture investor support. But some activists and scientists are critical of the murky science of de-extinction.
The company got pushback over its recent claims that it resurrected the dire wolf. But the debate misses the point, said Beth Shapiro, Colossal's chief science officer, to CNN. The scientists successfully resurrected the "functional essence" of the dire wolf. Still, this clarification begs the question: Is de-extinction even a thing?
Is it scientifically possible? DNA recovered from long-dead creatures is "profoundly degraded, chewed up by time and bacteria," and only fragments are recovered, said geneticist and de-extinction critic Adam Rutherford at The Guardian. These fragments comprise a "tiny proportion of the total amount of DNA in a living creature." Much of what gets lost has a "function in living cells" and is "species-specific." This makes the proposed process of de-extinction much different than the famous 1996 cloning of the sheep Dolly, whose complete genome was taken from a living sheep.
Are de-extinction claims true? No matter how cute the dire wolf pups might be, Colossal's claims about them are "absolute bollocks," Rutherford said on his Punctuated Equilibrium substack. The three pups are "by any sensible definition, genetically engineered gray wolves," an entirely different species, and "dire wolves remain very extinct." These pups have been "experimented on for no good reason — not for medical knowledge, not for conservation reasons, just for business."
The company's efforts to de-extinct animals like the woolly mammoth are "as far as conservation efforts go incredibly misguided," conservation expert Nitin Sekar said at Ars Technica. Ultimately, Colossal's efforts will not "end up being about helping wild elephants or saving the climate" but "creating creatures for human spectacle." If conservation is the goal, Colossal should be "willing to pivot from a project that grabs news headlines to ones that would likely make positive differences."
Despite ethical questions, the birth of the pups is a "major breakthrough in genetics," said Michael Knapp, an anatomy professor at New Zealand's University of Otago, to The Washington Post. It's easy to "brush attempts to bring back extinct species off as vanity projects without purpose," but that would "ignore the technological breakthroughs." However, whether this is an "avenue that should be further pursued is a highly complex question." |