The US health secretary's cancellation of nearly $500 million-worth of funding for multiple mRNA vaccine projects has been described as a dangerous decision for public health.
Robert F. Kennedy Jr, a long-standing vaccine sceptic, is pulling funding for work on vaccines and therapeutics that help protect us against respiratory viruses like Covid-19, influenza and H5N1 bird flu.
What exactly is RFK Jr scrapping?
On Tuesday, Kennedy said there would be a "co-ordinated wind down" of mRNA vaccine development programmes at the US government's biodefence agency, including the cancellation or modification of 22 separate projects. His reasons seem to centre on his long-held doubts about the safety and effectiveness of these vaccines.
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First used at scale during the Covid-19 pandemic, mRNA vaccines deliver "instructions for making a harmless piece of protein" that's otherwise "identical to one found in a particular virus or bacterium", said UK Health Security Agency. "Our immune system recognises it as a foreign body and starts to produce antibodies which can attack the protein if it encounters it again in the form of the 'real' virus". This type of vaccine can be produced, modified and distributed much more quickly than a traditional vaccine – which introduces dead or weakened versions of the virus itself.
This speeding up of the production process is one of the key reasons mRNA vaccines have "long been distrusted by vaccine sceptics". Kennedy himself referred to mRNA vaccine technology as "troubled", and called older "whole-cell" vaccine technology "safer".
Kennedy also said that "mRNA vaccines don't perform well against viruses that infect the upper respiratory tract" – a "wildly incorrect statement", according to Brown University pandemic preparedness expert Jennifer Nuzzo, said The New York Times.
What does it mean for the US?
Kennedy's move has caused horror among experts in the field. "I don't think I've seen a more dangerous decision in public health in my 50 years in the business," Mike Osterholm, a University of Minnesota expert on infectious diseases and pandemic preparations, told Sky News.
Experts in vaccine research say this news is a "real blow" to efforts to prepare for the next pandemic, said Vox. The US will "now be further behind in developing new vaccines" – a consequence that's "likely to be measured in human lives".
What does this mean for rest of the world?
Consequences of the funding cuts could "deepen if other nations follow the US lead", said Newsweek, or if private investment in rapid vaccine development "wanes".
If "one of the largest markets in the world" decides not to invest in mRNA, manufacturers "will be less willing to invest their own resources in the technology", Andrew Pollard, director of the Oxford Vaccine Group that led the development of the Oxford-AstraZeneca Covid-19 vaccine, told The Guardian. The "wider implications of this decision could be that the world is less safe".
Despite his recent protestations to the contrary, Kennedy's move (and past statements) reinforce the impression that he has a more general anti-vaccine stance – and this, too, could also have profound consequences, especially when vaccination rates are already falling globally. "Misguided beliefs" like Kennedy's are "likely to cause unnecessary suffering and death, particularly in children", said David Elliman, an honorary associate professor at UCL and a clinical adviser to the UK National Screening Committee.
Kennedy's cuts will unquestionably harm the US but they also present an opportunity for scientists elsewhere in the global community to take the lead, Kate Bingham, who led the UK's vaccine taskforce during the early part of the Covid pandemic, told The Guardian. The UK already has collaborations with two firms working on mRNA technologies, BioNTech and Moderna, and has invested in a new £26.4 million RNA Centre of Excellence to develop new mRNA therapies and vaccines.
