New medicine can be found even in the iciest of locations. During an expedition to Antarctica, scientists discovered a species of sea squirt that may promise a new cancer treatment. The marine organism contains bacteria capable of producing a toxin that could eventually become a widely available drug. However, research still needs to be done on the species and bacteria before it can be tested on humans.
The cancer-fighting sea squirt, also called an ascidian, was first discovered 20 years ago and identified as a potential cancer therapy. The bacterium in the organism, Candidatus Synoicihabitans palmerolidicus, can “produce the metabolite palmerolide A, which kills melanoma cells without causing too much harm to healthy human cells”, said Discover.
Scientists have now conducted a second expedition to Antarctica to “better understand the compound and explore whether it could someday contribute to new therapies for patients battling melanoma”, said a news release from the University of South Florida.
The researchers have also tested the sea squirt’s bacteria on melanoma cells in mice. “The good news is it didn’t kill the mice,” Bill Baker, a chemistry professor at the university who led the first expedition and advised the second one, told The Guardian. “It did kill their cancer, so we know it has the physiological properties to act like a drug.”
While the sea squirt shows promise, the “pathway to producing a safe and effective anti-melanoma drug, with approval for use in humans, is long”, said The Guardian. It would “require a succession of strictly regulated and ever-expanding trials even after a drug was formulated”. Still, the knowledge gained from this expedition “could significantly advance the timeline”.
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