Alzheimer’s gene neutralised in human brain cells for first time
Development comes after scientists switch away from testing on mouse cells

Scientists have claimed a major breakthrough in the battle against Alzheimer’s by neutralising a key gene that significantly increases the risk of developing the disease.
A team at Gladstone Institutes, in California, “successfully identified the protein associated with the high-risk apoE4 gene and then managed to prevent it damaging human neuron cells”, reports The Daily Telegraph.
The research, published in the journal Nature, reveals how the apoE4 gene confers its risk for Alzheimer’s in human brain cells.
Subscribe to The Week
Escape your echo chamber. Get the facts behind the news, plus analysis from multiple perspectives.

Sign up for The Week's Free Newsletters
From our morning news briefing to a weekly Good News Newsletter, get the best of The Week delivered directly to your inbox.
From our morning news briefing to a weekly Good News Newsletter, get the best of The Week delivered directly to your inbox.
“What’s more, they were able to erase the damage caused by apoE4 by changing it, with a small molecule, into a harmless apoE3-like version”, says news website ScienceDaily.
Having one copy of the apoE4 gene “more than doubles a person’s likelihood of developing Alzheimer’s disease, whereas having two copies increases the risk 12-fold”, says the Telegraph.
Previous studies “have indicated that roughly one in four people carry the gene”, the newspaper reports.
The latest breakthrough adds to hopes of finding a drug treatment that could halt the onset of the disease. The researchers have urged caution, however, pointing out that the neutralising process has only been tried in lab conditions as yet.
The development came after the California team decided to shun traditional testing methods.
Most Alzheimer’s research and drug development “are done in mouse models of the disease”, says ScienceDaily.
“Drug development for Alzheimer's disease has been largely a disappointment over the past ten years,” says lead study author Yadong Huang. “Many drugs work beautifully in a mouse model, but so far they’ve all failed in clinical trials. One concern within the field has been how poorly these mouse models really mimic human disease.”
Following a succession of clinical trial failures, Huang and his colleagues decided to use human cells to model the disease and test new drugs, leading to their discovery.
Sign up for Today's Best Articles in your inbox
A free daily email with the biggest news stories of the day – and the best features from TheWeek.com
-
What happens if tensions between India and Pakistan boil over?
TODAY'S BIG QUESTION As the two nuclear-armed neighbors rattle their sabers in the wake of a terrorist attack on the contested Kashmir region, experts worry that the worst might be yet to come
-
Why Russia removed the Taliban's terrorist designation
The Explainer Russia had designated the Taliban as a terrorist group over 20 years ago
-
Inside the Israel-Turkey geopolitical dance across Syria
THE EXPLAINER As Syria struggles in the wake of the Assad regime's collapse, its neighbors are carefully coordinating to avoid potential military confrontations
-
'Like a sound from hell': Serbia and sonic weapons
The Explainer Half a million people sign petition alleging Serbian police used an illegal 'sound cannon' to disrupt anti-government protests
-
The arrest of the Philippines' former president leaves the country's drug war in disarray
In the Spotlight Rodrigo Duterte was arrested by the ICC earlier this month
-
Ukrainian election: who could replace Zelenskyy?
The Explainer Donald Trump's 'dictator' jibe raises pressure on Ukraine to the polls while the country is under martial law
-
Why Serbian protesters set off smoke bombs in parliament
THE EXPLAINER Ongoing anti-corruption protests erupted into full view this week as Serbian protesters threw the country's legislature into chaos
-
Who is the Hat Man? 'Shadow people' and sleep paralysis
In Depth 'Sleep demons' have plagued our dreams throughout the centuries, but the explanation could be medical