Wipe down the surface. Move aside any “light items,” such as the phone and keyboard. If the surface is laminate or another washable material, opt for an all-purpose cleaner. If wood, try a water-vinegar mix.
Delete dust. “Nothing seems to attract dust like electronics do.” Use micro-fiber cloths or wipes, specially made for electronics, to avoid scratching surfaces or leaving lint behind. Lightly go over the monitor. Then dampen the cloth and “buff away grime” on the rest of the computer.
Hit the keys. Keyboards are “one of the dirtiest, germiest” surfaces in an office. To clean, unplug and hold upside-down over the trash. Gently tap the back to loosen any crumbs. A paintbrush can “whisk dust from all the openings and crevices,” while a cotton ball moistened with rubbing alcohol helps clean the surface of the keys.
Source: Good Housekeeping