Why do vaccines take so long to produce?
Scientists believe developing a coronavirus vaccine could take at least 18 months

Donald Trump has angered European politicians after allegedly offering a German company $1bn (£800m) for exclusive rights to a future coronavirus vaccine.
The president’s offer prompted one German minister to warn Trump that “Germany is not for sale”, while the company in question – biopharmaceutical firm CureVac – says that any vaccine will be “for the whole world and not individual countries”.
The World Health Organization (WHO) has warned that it may be 18 months before a vaccine for the coronavirus is publicly available, despite a global effort to find a treatment.
The Week
Escape your echo chamber. Get the facts behind the news, plus analysis from multiple perspectives.

Sign up for The Week's Free Newsletters
From our morning news briefing to a weekly Good News Newsletter, get the best of The Week delivered directly to your inbox.
From our morning news briefing to a weekly Good News Newsletter, get the best of The Week delivered directly to your inbox.
So why does it take so long to develop a vaccine?
How do vaccines work?
As the BBC reports, vaccines work by introducing a small amount of a virus or bacteria to the immune system. This means that when the body comes into contact with the illness for real, it recognises it as an “invader” and knows how to fight it.
This is how vaccinations for seasonal flu, measles, mumps and rubella are made, by introducing weak versions of those viruses – that cannot cause a full-blown infection – to the immune system.
A free daily email with the biggest news stories of the day – and the best features from TheWeek.com
But, as the BBC’s health and science correspondent James Gallagher notes, the work to develop a coronavirus vaccine is using “newer, and less tested, approaches called ‘plug and play’ vaccines”.
This method sees scientists lifting sections of the coronavirus’s genetic code and putting it into other, totally harmless, viruses. This, Gallagher reports, means that you can “infect” someone with the bug, giving some immunity against infection from the real coronavirus.
–––––––––––––––––––––––––––––––For a round-up of the most important stories from around the world - and a concise, refreshing and balanced take on the week’s news agenda - try The Week magazine. Start your trial subscription today –––––––––––––––––––––––––––––––
What stage of development are we at?
Rob Grenfell, director of health and biosecurity at Australia’s national science agency, writes that China first shared the genetic code of the virus in early January.
By late January, he says, the virus was successfully grown outside China for the first time. This allowed researchers in other countries to gain access to a live sample of the virus, kick-starting the “plug and play” experiments to develop a vaccine.
WHO chief Tedros Adhanom Ghebreyesus has said that a vaccine could be available within 18 months, but first scientists must understand the virus’s characteristics and behaviour in humans.
Once this is achieved, Grenfell says, animal testing can begin, before the vaccine is tested in trials using humans to ensure its safety.
The German company Trump allegedly tried to approach says that it is hoping to have an experimental vaccine developed by June or July. This will then have to be extensively tested in human trials.
US-based biotechnology company Novavax began testing a number of new coronavirus vaccines on animals in late February. It has been reported that these tests should identify the “optimal” vaccine to then test on humans.
Grenfell notes that vaccines have historically taken two to five years to develop. However, he adds that with a global effort to produce a viable coronavirus vaccine, researchers could potentially develop a vaccine in a much shorter time.
What are the challenges?
As The Guardian reports, the timeline of 18 months for a vaccine assumes that “there will be no hitches” in the process of developing and testing.
Annelies Wilder-Smith, professor of emerging infectious diseases at the London School of Hygiene and Tropical Medicine, told the paper: “Like most vaccinologists, I don’t think this vaccine will be ready before 18 months.”
As the paper notes, most vaccines take a decade or more to get regulatory approval, meaning that 18 months would be “extremely fast”.
Another problem is that once developed, large quantities of the vaccines are going to be needed at very short notice. This, the Guardian reports, could be a stumbling block as many organisations in the Covid-19 vaccine race “simply don’t have the necessary production capacity”.
Financing the research and production of a vaccine is also risky for pharmaceutical companies, as many candidates do not ever make it into production.
The global vaccine market is expected to grow to $60bn (£46bn) this year, but profits are by no means guaranteed in the field, mainly because of the money and time spent on the process of getting the drug to market.
However, as Grenfell notes, the knowledge gained by the global scientific community in the race to develop a vaccine following the 2003 Sars outbreak has given us a “head-start” on developing one for coronavirus.
-
Bluetoothing: the phenomenon driving HIV spike in Fiji
Under the Radar ‘Blood-swapping’ between drug users fuelling growing health crisis on Pacific island
-
Marisa Silver’s 6 favorite books that capture a lifetime
Feature The author recommends works by John Williams, Ian McEwan, and more
-
Book reviews: ‘We the People: A History of the U.S. Constitution’ and ‘Will There Ever Be Another You’
Feature The many attempts to amend the U.S. Constitution and Patricia Lockwood’s struggle with long Covid
-
Behind the ‘Boriswave’: Farage plans to scrap indefinite leave to remain
The Explainer The problem of the post-Brexit immigration surge – and Reform’s radical solution
-
RFK Jr.’s anti-vaccine crusade comes under fire
Feature Robert F. Kennedy Jr. faced a heated hearing as senators accused him of lying and spreading chaos
-
Hostile architecture is 'hostile — to everybody'
Instant Opinion Opinion, comment and editorials of the day
-
RFK Jr. faces bipartisan heat in Senate hearing
Speed Read The health secretary defended his leadership amid CDC turmoil and deflected questions about the restricted availability of vaccines
-
Florida aims to end all state vaccine requirements
Speed Read Health Secretary Robert F. Kennedy Jr. continues to cut vaccine access and install anti-vaccine activists at the FDA and CDC
-
RFK Jr. names new CDC head as staff revolt
Speed Read Kennedy installed his deputy, Jim O'Neill, as acting CDC director
-
White House fires new CDC head amid agency exodus
Speed Read CDC Director Susan Monarez was ousted after butting heads with HHS Secretary Robert F. Kennedy Jr. over vaccines
-
What difference will the 'historic' UK-Germany treaty make?
Today's Big Question Europe's two biggest economies sign first treaty since WWII, underscoring 'triangle alliance' with France amid growing Russian threat and US distance