Ten Things You Need to Know Today: Tuesday 19 Apr 2016

1. Gove: Leaving the EU would be 'liberation'

Michael Gove, the Justice Secretary, is to say today that leaving the EU would be a liberating act of "patriotic renewal" as campaigning intensifies ahead of the 23 June vote on membership of the bloc. Yesterday, the Treasury said leaving would cost every household in the UK £4,300, a figure Gove will decry as scaremongering.

Remain-voting City lobby group calls for 'dramatic Brexit U-turn'

2. Ecuador earthquake death toll passes 410

More than 410 people are now known to have died in the devastating earthquake that hit Ecuador on Saturday evening. The magnitude 7.8 tremor was the biggest in the country for more than 40 years and could be felt as far away as Colombia. The search for survivors continues. The cost of rebuilding will be billions of dollars.

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3. Drug mixture 'wipes out skin cancer'

Combining two existing immunotherapy drugs can prolong patients' lives and completely wipe out skin cancer, a new study has found. Doctors in the US gave patients with advanced melanoma either the drug ipilimumab on its own or in combination with nivolumab. Those taking both fared far better than the others.

Skin cancer: Breakthrough drug combination approved

4. Taliban explosion kills dozens in Kabul

The Taliban has claimed responsibility for a massive explosion in central Kabul which killed 28 people and injured more than 300. The blast comes after the extremist group warned of a "spring offensive". A suicide bomber detonated a car near Afghanistan's main security agency and gunmen then stormed the area.

5. All-out doctors' strike may not be 'right option'

The General Medical Council has warned that the first ever all-out strikes by junior doctors, planned for next week, might not be the "right option" as some hospitals could struggle to cope. It urged those taking action to "satisfy themselves" that patients would be safe. The strikes were called after the government said it would impose a new contract on doctors.

6. Migrant crisis: 'Hundreds' die at sea

Survivors of a capsized boat carrying would-be migrants in the Mediterranean say up to 500 people were drowned. The figure has not been confirmed by coastguards and is said by the UN to be "inaccurate". The boat was heading from Libya to Italy and the 41 survivors were from Ethiopia, Somalia, Sudan and Egypt.

7. Replica of Palmyra arch erected in Trafalgar Square

A marble replica of the Arch of Triumph, an ancient Syrian monument destroyed by Islamic State in Palmyra, has been erected in Trafalgar Square. The two-thirds scale model will be on display in London for three days before moving to other locations around the world, including New York and Dubai. The replica of the Roman arch was build by the Institute of Digital Archaeology.

8. India will not demand return of diamond

The Indian government has said it will not formally demand the return of the Kohinoor diamond from the UK. The 105-carat gem, once the biggest known in the world, has been part of the crown jewels for 150 years. India's solicitor-general, Ranjit Kumar, said yesterday it had been "neither stolen nor forcibly taken away".

9. Netherlands: Electric cars only by 2025

The Dutch parliament is close to banning the sale of new petrol and diesel cars from 2025, in favour of electric vehicles. The motion was passed by the lower house but will need to be agreed by the senate to become law. The original proposal would have banned all petrol and diesel cars from the roads but has been watered down.

Dutch MPs vote to ban sales of petrol and diesel cars

10. Briefing: The small-screen appeal of The People v OJ Simpson

The People v OJ Simpson: American Crime Story drew to a close last night, after bringing one of the most famous US murder trials back into the spotlight 21 years on. In the US, it is cable's most watched new series this year, while critics in the UK have called it television's "most gripping court drama in a long time". And despite knowing the outcome from the start, viewers have been mesmerised by "the chance to reassess the case through the prism of history".

OJ Simpson to be released: Key moments of the 'trial of the century'