European Union regulators on Wednesday hit Google with a record €4.3 billion ($5 billion) fine for antitrust violations, BBC reports. The European Commission said Google abused its Android market dominance by inserting its own search engine and Chrome apps into the widely used operating system for smartphones and tablets. The regulators also said Google did other things to block competition, such as paying "certain large manufacturers and mobile network operators" to exclusively bundle its search app on handheld devices.

The fine far surpassed Google's previous $2.7 billion record-breaking fine, The Verge reports, which the EU imposed last year, saying Google had manipulated search results. Google parent Alphabet has 90 days to change its business practices or face further penalties. Harold Maass

One day after first lady Melania Trump's office called for her to get the boot, Mira Ricardel is no longer the deputy national security adviser.

"Mira Ricardel will continue to support the president as she departs the White House to transition to a new role within the administration," White House press secretary Sarah Huckabee Sanders said in a statement Wednesday evening. "The president is grateful for Ms. Ricardel's continued service to the American people and her steadfast pursuit of his national security priorities."

On Tuesday, the first lady's communications director, Stephanie Grisham, released a statement blasting Ricardel, saying she "no longer deserves the honor of serving in this White House." Sanders, White House chief of staff John Kelly, and other administration officials were all shocked by the statement, CNN reports.

A person familiar with the situation said during Melania Trump's trip to Africa in October, Ricardel fought with her staff over several things, including who would sit where on the plane. Ricardel was a key ally of National Security Adviser John Bolton, but often clashed with Kelly and his deputy, Zach Fuentes, as well as Defense Secretary James Mattis. CNN reports that Kelly and Fuentes believe Ricardel leaked negative stories about them, and she angered Mattis by blocking some of his choices to fill Pentagon positions, because they were former Obama administration officials. Catherine Garcia

Lisa Storie-Avenatti, the wife of Stormy Daniels' lawyer Michael Avenatti, is refuting reports that she was involved in a domestic dispute that led to Avenatti's arrest Wednesday in Los Angeles.

TMZ first reported Avenatti's arrest on suspicion of domestic violence Wednesday afternoon, saying his estranged wife was injured and filed a report against him on Tuesday. Storie-Avenatti's lawyer quickly released a statement to BuzzFeed News, saying that the TMZ article "is not true as it pertains to my client." Storie-Avenatti "was not subject to any such incident on Tuesday night," the attorney said. "Further, she was not at Mr. Avenatti's apartment on the date that this alleged incident occurred. My client states that there has never been domestic violence in her relationship with Michael and that she has never know Michael to be physically violent toward anyone."

In an update to the original article, TMZ says initially a law enforcement official told the outlet the "alleged victim was Avenatti's estranged wife. We now know it was not. The incident involved a different woman." Avenatti filed for divorce last November. Catherine Garcia

President Trump on Wednesday announced he is in favor of a bipartisan proposal to rewrite the country's prison and sentencing laws.

"It's the right thing to do," he said during an event at the White House. Called the First Step Act, this tentative legislative package adds to a prison overhaul bill the House passed earlier this year. It includes shortening mandatory minimum sentences for some nonviolent drug offenses and changes the "three strikes" penalty from life in prison to 25 years, The New York Times reports. It will also roll back some of the federal policies from the 1980s and 1990s that disproportionately affect blacks and fund anti-recidivism programs.

Trump's son-in-law and senior adviser Jared Kushner is the biggest proponent of the package in the administration, and presented the deal to Trump on Tuesday. Trump urged Congress to agree to a final bill quickly so he can sign it. There are 2.2 million prisoners in the United States. Catherine Garcia

Michael Avenatti, the attorney representing adult film star Stormy Daniels in her case against President Trump, was arrested Wednesday on suspicion of felony domestic violence.

A spokesman for the Los Angeles Police Department told The Hollywood Reporter a report about the alleged abuse was filed on Tuesday.

A law enforcement official told TMZ Avenatti's estranged wife filed the report, and her face was "swollen and bruised." The official also said there was a confrontation between the two on Wednesday, which led to the police getting involved. The couple married in 2011.

UPDATE, 7:39 p.m. EST: An attorney for Avenatti's wife, Lisa Storie-Avenatti, told BuzzFeed News that TMZ's story saying she was injured is false. "Ms. Storie-Avenatti was not subject to any such incident on Tuesday night," the attorney said in a statement, adding that she was also not at his apartment on Wednesday. "My client states that there has never been domestic violence in her relationship with Michael and that she has never known Michael to be physically violent toward anyone." Catherine Garcia

Every day, 20 Americans die waiting for an organ transplant.

Scientists have long tried xenotransplantation — using organs from other species in humans — to combat a short supply of organ donors, with little success. But this method is seemingly on the verge of a massive breakthrough, and it could provide "a definitive solution to the organ crisis," a transplant researcher tells The New York Times Magazine.

The first attempt at xenotransplantation came in 1984, when doctors replaced a newborn's failing heart with a baboon's. The baby lived less than three weeks, but the story inspired a new generation of xenotransplantation researchers who are focused less on primates and more on inbred, pathogen-free pigs, per the Times Magazine.

Given primates' long breeding cycles, using them to essentially create an organ farm wasn't sustainable. But pigs ordinarily have multiple piglets in less than four months, and they're "uncannily humanlike in organ size and function," the Times Magazine notes. The main xenotransplantation complication came from humans' and pigs' divergent immune systems, which meant a human would probably reject swine tissue.

That's where Columbia University immunologist David Sachs' pathogen-free swine farm comes in. Sachs' pigs are genetically engineered so their organs grow to "about the same size as a human's," the Times Magazine writes, and Sachs says they're "very likely the most inbred large animals on Earth." Those swine, combined with what scientists call "brute-force immunotherapy," could lead to success in the first "pig-to-human skin graft" slated for later this month. If it's successful, a full kidney replacement for dialysis patients will come next. Read more at The New York Times Magazine. Kathryn Krawczyk

The secret to winning the lottery just might be persistence.

After playing the same numbers for 25 years, a man in Harlem, New York City, found a little bit of luck and won the largest jackpot in New York state lottery history — $343 million, reports Time. Robert Bailey, a retired federal government employee, was revealed as the Powerball winner at a news conference at the Resorts World Casino New York City on Wednesday.

Bailey, 67, purchased his ticket at a deli in Harlem ahead of the October 27 drawing, and was shocked when he saw the winning numbers online that night.

"I tried to remain calm and sat down to watch some shows I had on my DVR. I didn't sleep the rest of the night," he said, reports The Washington Post.

Bailey chose to receive the money in a lump sum, which, after taxes, is roughly $125 million, says Time. He will split the jackpot with a woman in Iowa, per the Post.

During the press conference, Bailey revealed that he plans to continue playing the lottery, and that he played Wednesday morning. He plans to use the winnings to buy a house for his mother and to travel. He also wants to use the money for the greater good.

“I plan to give back to Manhattan; that's where I'm from,” Bailey said to the Post. “I still want to be me. I can't let money change me. I'm going to keep doing the right thing.” Taylor Watson