A growing body of evidence suggests that a compound called choline plays an underappreciated role in our health, particularly in our brains. New research suggests low levels of choline in obese people could contribute to brain aging and potentially trigger the kind of neurodegenerative changes that can lead to Alzheimer’s disease. The study — in addition to others linking choline to higher bone density, better memory and improved mental health — has led some scientists to classify choline as a “wonder nutrient” that has been “hugely overlooked,” said BBC Future.
What’s choline? This essential nutrient is not a vitamin or a mineral but an organic compound closely related to the B-vitamin group. Humans need choline for numerous bodily functions, including liver function and the production of acetylcholine, a brain chemical that plays a major role in memory, thinking and learning.
We produce small amounts of choline in our livers, but to get enough, we need to get it through food. The most common sources are eggs, red meat, chicken, potatoes, yogurt, fish, leafy greens and kidney beans. The average adult needs about 425 milligrams a day (about three eggs’ worth). Pregnant and breastfeeding women need more, as choline “plays a key role” in the healthy development of a baby’s brain, said The Telegraph.
What did the latest study find? Researchers from Arizona State University analyzed key chemical levels and biomarkers in 15 people with obesity and compared them with those of 15 people of a healthy weight. The results, published in the journal Aging and Disease, show that those with obesity had less circulating choline, more biomarkers associated with inflammation, and higher levels of blood proteins, indicating neuron damage.
The small study didn’t prove cause and effect, but the “big picture” is that obesity, choline and the accelerated brain aging that can lead to dementia “could all be connected,” said ScienceAlert. Low levels of choline could be an “early warning sign” of diseases such as Alzheimer’s, and a “boost” in choline levels could be an effective “preventive measure.”
What about other studies? Low levels of choline have been identified as having a “significant link” with anxiety disorders, according to a meta-analysis published last month in Molecular Psychiatry. University of California researchers looked at data from 25 studies and found that levels of choline were 8% lower in the brains of people with anxiety disorders. That “doesn’t sound like that much,” study co-author Richard Maddock said to New Atlas, but “in the brain, it’s significant.” |