Breast cancer calculator: how it works
‘Game-changing’ system analyses genetics and lifestyle factors to calculate overall risk

A groundbreaking new system that can predict the extent to which a patient is at risk of breast cancer may soon be available in GP surgeries.
According to a study by Cancer Research UK, researchers have created an online calculator that takes into account more than 300 genetic indicators for the disease, alongside factors including the patient’s weight, age at menopause, alcohol consumption, use of hormone replacement therapy and hereditary factors.
Although these individual factors are not indicators of high breast cancer risk, experts say that combining this information with genetic data can give the most comprehensive assessment possible.
Subscribe to The Week
Escape your echo chamber. Get the facts behind the news, plus analysis from multiple perspectives.

Sign up for The Week's Free Newsletters
From our morning news briefing to a weekly Good News Newsletter, get the best of The Week delivered directly to your inbox.
From our morning news briefing to a weekly Good News Newsletter, get the best of The Week delivered directly to your inbox.
Sky News reports that the method - outlined in a paper published in Nature’s Genetics in Medicine journal - is currently being tested by some GPs, practice nurses and genetic counsellors.
“It is hoped it will allow doctors to tailor screening for specific individuals depending on risk,” the broadcaster adds. “For example, it could indicate when a patient should be first called for screening and how often.”
Breast cancer is the most common cancer in the UK, with almost 55,000 women diagnosed each year, many of whom have exhibited genetic and lifestyle factors that might indicate an increased risk.
“Although individually some of these things have a small impact on the likelihood of developing the disease, researchers found that by considering all of them at once, plus family history and genetics, they can identify groups of women who have different risks of developing breast cancer,” reports the EurekAlert! science news site.
Professor Antonis Antoniou, lead author of the research at the University of Cambridge, said: “This is the first time that anyone has combined so many elements into one breast cancer prediction tool.
“It could be a game changer for breast cancer because now we can identify large numbers of women with different levels of risk – not just women who are at high risk.”
He added that while more research and trials are needed, “we hope this means more people can be diagnosed early and survive their disease for longer”.
Sign up for Today's Best Articles in your inbox
A free daily email with the biggest news stories of the day – and the best features from TheWeek.com
-
The secrets of lab-grown chocolate
Under The Radar Chocolate created 'in a Petri dish' could save crisis-hit industry
By Chas Newkey-Burden, The Week UK
-
Trade war with China threatens U.S. economy
Feature Trump's tariff battle with China is hitting U.S. businesses hard and raising fears of a global recession
By The Week US
-
Corruption: The road to crony capitalism
Feature Trump's tariff pause sent the stock market soaring — was it insider trading?
By The Week US
-
Washwood Heath: Birmingham's pioneering neighbourhood health service
In the Spotlight NHS England chair says there is a 'really good argument this is the model for the future'
By The Week UK
-
Why are more young people getting bowel cancer?
The Explainer Alarming rise in bowel-cancer diagnoses in under-50s is puzzling scientists
By Elizabeth Carr-Ellis, The Week UK
-
The UK's first legal drug consumption room
The Explainer 'Potentially transformative moment in UK drugs policy' as The Thistle opens in Glasgow
By The Week UK
-
How can the UK solve the adult social care crisis?
Today's Big Question New commission announced to turn our buckling care sector around: yet more delay or finally a way forward?
By Elizabeth Carr-Ellis, The Week UK
-
Five medical breakthroughs of 2024
The Explainer The year's new discoveries for health conditions that affect millions
By Adrienne Wyper, The Week UK
-
Should blood donors be paid?
The Explainer Financial rewards would help fill NHS shortfall but bring risk of contamination and exploitation, WHO warns
By The Week UK
-
UK gynaecological care crisis: why thousands of women are left in pain
The Explainer Waiting times have tripled over the past decade thanks to lack of prioritisation or funding for women's health
By Harriet Marsden, The Week UK
-
A 'transformative' gene therapy for haemophilia B
The Explainer Costly treatment that could be 'truly life-changing' for patients with rare blood disorder gets funding boost
By Julia O'Driscoll, The Week UK