Researchers think an experimental drug might prevent COVID-19 blood clots


COVID-19 is a respiratory illness that also causes inflammation, but a third of hospitalized coronavirus patients develop dangerous blood clots as well. Scientists at Britain's Imperial College London hypothesize that the clots are a byproduct of a hormonal imbalance caused by an enzyme the coronavirus deactivates to invade cells, BBC News reports, and they are preparing a clinical trial to see if the experimental drug TRV027 can fix that imbalance. The trial, funded by the British Heart Foundation, begins next month, with about 60 patients getting either TRVO27 or a placebo.
TRVO27, made by Trevena, "works to rebalance hormones involved in blood pressure, water, and salt," BBC News says. It was originally developed to treat acute heart failure, though it failed to live up to expectations in a trial.
Researchers have not yet found a proven effective treatment against COVID-19, though at least 10 antiviral drugs, numerous anti-inflammatory treatments, and convalescent plasma are all being tried on experimental bases. The experimental antiviral drug Remdesivir has shown promise, too. Some researchers hope a combination of several drugs will be effective at treating the complicated virus.
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Peter has worked as a news and culture writer and editor at The Week since the site's launch in 2008. He covers politics, world affairs, religion and cultural currents. His journalism career began as a copy editor at a financial newswire and has included editorial positions at The New York Times Magazine, Facts on File, and Oregon State University.
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