Book of the week: Empire of Pain
Patrick Radden Keefe examines the dynasty behind the opioid crisis
“Some books make you so angry you want to chuck rocks at the bad guys they expose,” said John Arlidge in The Sunday Times. “This book is one of those.” It tells the story of the Sackler family, whose firm, Purdue Pharma, created the painkiller OxyContin, which “fuelled America’s opioid crisis”.
Although this isn’t the first book about the crisis, it goes further than any other: Patrick Radden Keefe, a writer for The New Yorker, draws on newly released court documents and more than 200 interviews to show how the Sacklers derived a multibillion-dollar fortune from a pill they “knew was highly addictive”.
The epidemic it spawned has destroyed communities, and killed half a million people – “more than died in all the wars the country has fought since 1945”. And yet for decades, the Sacklers “got away with it” – even becoming celebrated philanthropists, thanks to their lavish donations to museums and galleries.
Subscribe to The Week
Escape your echo chamber. Get the facts behind the news, plus analysis from multiple perspectives.
Sign up for The Week's Free Newsletters
From our morning news briefing to a weekly Good News Newsletter, get the best of The Week delivered directly to your inbox.
From our morning news briefing to a weekly Good News Newsletter, get the best of The Week delivered directly to your inbox.
The three Sackler brothers, Arthur, Mortimer and Raymond, were born to Jewish immigrants in Brooklyn, became doctors and bought Purdue in 1952, said Joanna Walters in Literary Review. Arthur became a “leading light in the nascent medical advertising industry” – a “toxic marriage of pills and ad men” – and deployed “all kinds of slippery tactics” to make Valium the most widely abused prescription drug of its day.
Where he led, his descendants followed, said Samanth Subramanian in The Guardian. When OxyContin was launched in 1996, the Sacklers relied on studies they themselves had funded to bolster the claim that it was less addictive than other opioids. The drug was approved by the Food and Drug Administration (FDA) – by an official who a year later was “working at Purdue, earning $400,000 a year”.
Equally amoral was Purdue’s marketing of OxyContin, said Melanie Reid in The Times. Sales reps “fanned out across the US”, targeting doctors in regions where many people lived with chronic pain. Patients were offered free 30-day taster courses, and doctors were incentivised to “titrate up” – gradually increase the dose. When it became clear that thousands were becoming addicted, Purdue shifted the blame to the drug users – as Arthur Sackler had done with Valium.
“It is a measure of great and fearless investigative writing that it achieves retribution where the law could not.” To this day, no Sackler has ever faced criminal prosecution – and the family has retained most of its billions in personal wealth. “But Radden Keefe has, word by forensic word, dismantled what mattered most to them: their reputation.”
Pan Macmillan 560pp £20; The Week Bookshop £15.99
The Week Bookshop
To order this title or any other book in print, visit theweekbookshop.co.uk, or speak to a bookseller on 020-3176 3835. Opening times: Monday to Saturday 9am-5.30pm and Sunday 10am-4pm.
Sign up for Today's Best Articles in your inbox
A free daily email with the biggest news stories of the day – and the best features from TheWeek.com
-
Band Aid 40: time to change the tune?
In the Spotlight Band Aid's massively popular 1984 hit raised around £8m for famine relief in Ethiopia and the charity has generated over £140m in total
By Rebekah Evans, The Week UK Published
-
Starmer vs the farmers: who will win?
Today's Big Question As farmers and rural groups descend on Westminster to protest at tax changes, parallels have been drawn with the miners' strike 40 years ago
By The Week UK Published
-
How secure are royal palaces?
The Explainer Royal family's safety is back in the spotlight after the latest security breach at Windsor
By Chas Newkey-Burden, The Week UK Published
-
Ed Park's 6 favorite works about self reflection and human connection
Feature The Pulitzer Prize finalist recommends works by Jason Rekulak, Gillian Linden, and more
By The Week US Published
-
6 fantastic homes in Columbus, Ohio
Feature Featuring a 1915 redbrick Victorian in German Village and a modern farmhouse in Woodland Park
By The Week Staff Published
-
Drawing the Italian Renaissance: a 'relentlessly impressive' exhibition
The Week Recommends Show at the King's Gallery features an 'enormous cache' of works by the likes of Leonardo, Michelangelo and Raphael
By The Week UK Published
-
Niall Williams shares his favourite books
The Week Recommends The Irish novelist chooses works by Charles Dickens, Seamus Heaney and Wendell Berry
By The Week UK Published
-
Patriot: Alexei Navalny's memoir is as 'compelling as it is painful'
The Week Recommends The anti-corruption campaigner's harrowing book was published posthumously after his death in a remote Arctic prison
By The Week UK Published
-
The Curious Case of Benjamin Button: a 'magical' show with 'an electrifying emotional charge'
The Week Recommends The 'vivacious' Fitzgerald adaptation has a 'shimmering, soaring' score
By The Week UK Published
-
Bird: Andrea Arnold's 'strange, beguiling and quietly moving' drama
The Week Recommends Barry Keoghan stars in 'fearless' film combining social and magical realism
By The Week UK Published
-
Kate Summerscale's 6 favorite true crime books about real murder cases
Feature The best-selling author recommends works by Helen Garner, Gwen Adshead, and more
By The Week US Published