Are pig-organ transplants becoming a reality?
US woman has gene-edited pig-kidney transplant, and scientists hope experimental surgery could save thousands of lives

The successful transplant of a gene-edited pig kidney into a human patient has raised hopes that cutting-edge technology can make pig organs safe for other transplant patients.
Towana Looney, a 53-year-old grandmother from Alabama whose (only) kidney was failing, is hopeful of "a new chance at life" after undergoing the operation, said NBC News. She is the fifth living person to receive a genetically modified pig organ. The previous four patients died shortly after the procedure, but Looney, who was in a much better state of health than previous recipients, and is now recovering well.
The pig kidney used by Looney's doctors, at NYU Langone Health in New York, had undergone a promising new combination of gene edits. The procedure is still experimental, and only available to patients who are left with no other option. But for the hundreds of thousands of people worldwide who are on the waiting list for an organ – and the many others who are ill but who have not yet made it onto a list – it offers a glimmer of hope.
Subscribe to The Week
Escape your echo chamber. Get the facts behind the news, plus analysis from multiple perspectives.

Sign up for The Week's Free Newsletters
From our morning news briefing to a weekly Good News Newsletter, get the best of The Week delivered directly to your inbox.
From our morning news briefing to a weekly Good News Newsletter, get the best of The Week delivered directly to your inbox.
How does the gene editing work?
Given the shortage of donor organs, scientists have tried for years to make animal-to-human transplants work. But "now they can edit pig genes", there's real hope – as long as the editing can "bridge the species gap" and "keep the human immune system from immediately attacking the foreign tissue," said The Independent.
Multiple companies are already "engineering pigs to be more humanlike" for optimal organ-transplant suitability, said AP News. Some of the gene edits are "knockouts", removing pig genes that would threaten the human immune system, while others insert human genes to lessen the risk of rejection and blood clots.
These engineered pigs could "someday provide an unlimited supply of kidneys, livers, hearts, and other organs" for human transplantation, alleviating the current "chronic shortage" and saving "thousands of patients every year", said NPR.
"It would change everything," Dr Robert Montgomery, director of NYU Langone's Transplant Institute, and the lead surgeon in Looney's operation, told the US news outlet. "I think it would revolutionise medicine, for sure."
What is the law on animal organ transplants?
Scientists have already transplanted pig organs into monkeys, baboons, and dead humans who'd donated their body for research, but transferring animal organs into living human recipients – or xenotransplantation – is still experimental, and controversial.
There's no specific legislation prohibiting xenotransplantation in the UK but there are animal welfare laws that touch on the issue. In the US, the Food and Drug Administration (FDA), which regulates public health, has not yet approved clinical trials but has allowed "compassionate-use" xenotransplants for patients who would not be able to receive a human donor organ in time to save their life.
In Looney's case, "very high levels of antibodies in her blood" made finding a match incredibly difficult, said NBC, and so "medical teams in Alabama and New York got special FDA clearance to use a gene-edited pig kidney from a Virginia-based biotech company".
What are the risks?
Some experts are concerned that, as things stand, the risks of pig-organ transplants may outweigh the benefits. "There's a lot of hope, but hope is not scientific evidence," L. Syd M Johnson, a bioethicist at SUNY Upstate Medical University in New York, told NPR. She's concerned that the current "series of one-off experiments by different research teams", each using "different protocols, organs with different gene edits, and patients who have run out of options" is "not a great way to do science".
Nor is it clear that enough is being done "to prevent the spread of pig viruses to people". It is "impossible to predict what the public-health implications might be" if that happens.
What next?
Following the success of Looney's operation, there is talk of getting FDA permission to "begin the world's first clinical trials" in 2025, said The Independent. Even then, "it will take years of clinical trials to prove whether xenotransplantation really could work," said AP News. But if it does, "porcine technology" companies envisage large facilities, "capable of producing up to 2,000 organs a year, in several places around the country."
Sign up for Today's Best Articles in your inbox
A free daily email with the biggest news stories of the day – and the best features from TheWeek.com
-
Help! Do we really need four Beatles biopics?
Talking Point The cast of Sam Mendes' Beatles biopics has been announced
By Chas Newkey-Burden, The Week UK Published
-
Test driving the Rolls-Royce Spectre Black Badge
The Week Recommends We take the most powerful Rolls-Royce ever built for a spin in Barcelona
By Fergus Scholes Published
-
Tuberculosis is seeing a resurgence, and it's only going to get worse
Under the radar The spread of the deadly infection is buoyed by global unrest
By Devika Rao, The Week US Published
-
Scientists want to fight malaria by poisoning mosquitoes with human blood
Under the radar Drugging the bugs
By Devika Rao, The Week US Published
-
Sea geniuses: all the ways that octopuses are wildly intelligent
The Explainer There's more to the tentacles than meets the eye
By Devika Rao, The Week US Published
-
Have we reached 'peak cognition'?
The Explainer Evidence mounts that our ability to reason, concentrate and problem-solve is in decline
By Harriet Marsden, The Week UK Published
-
Life after space: how will Nasa's stranded astronauts cope?
In the Spotlight Sunita 'Suni' Williams and Barry 'Butch' Wilmore are headed back to Earth after nine months on the ISS – but their greatest challenge may still lie ahead
By Harriet Marsden, The Week UK Published
-
There is a 'third state' between life and death
Under the radar Cells can develop new abilities after their source organism dies
By Devika Rao, The Week US Published
-
Scientists report optimal method to boil an egg
Speed Read It takes two temperatures of water to achieve and no fancy gadgets
By Peter Weber, The Week US Published
-
Scientists want to create an AI virtual cell
Under the radar Generative AI could advance medical research
By Devika Rao, The Week US Published
-
Mirror bacteria could pose major health risks
Under the Radar The experimental research could have dangerous impacts
By Devika Rao, The Week US Published