Gene-editing technique used to fight influenza could 'neutralize' coronavirus

PAC-MAN might be the key to munching our way through the coronavirus pandemic.

Okay, so the ghost-eating yellow blob has nothing to do with stopping a deadly virus. But a gene editing technique that borrows the video game's name could prove effective in "scrambling" COVID-19's genetic code and stopping it from growing, Science Daily reports.

Stanley Qi's bioengineering team at Stanford University started working last year to develop a way to use the CRISPR gene-editing tool to fight influenza, calling their technique "PAC-MAN." It sends a virus-killing enzyme into a virus' RNA — DNA's instructional messenger — that in turn tells the enzyme to attack the virus' genetic material.

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The arrival of the novel coronavirus, with no clear cure or treatment, presented a new opportunity for PAC-MAN. "By scrambling the virus's genetic code, PAC-MAN could neutralize the coronavirus and stop it from replicating inside cells," Science Daily writes.

But there was still the dilemma of how to actually deliver the PAC-MAN technique into lung cells. So after publishing a preprint of their study on the technique, Qi's lab found the Biological Nanostructures Facility at Berkeley Lab's Molecular Foundry. The facility focuses on using lipitoids to deliver therapies, and after a first test, the lipitoids "performed very well" at delivering the gene-scrambling treatment, Science Daily writes. Read more at Science Daily.