Gene-editing technique used to fight influenza could 'neutralize' coronavirus

Gene editing.
(Image credit: iStock)

PAC-MAN might be the key to munching our way through the coronavirus pandemic.

Okay, so the ghost-eating yellow blob has nothing to do with stopping a deadly virus. But a gene editing technique that borrows the video game's name could prove effective in "scrambling" COVID-19's genetic code and stopping it from growing, Science Daily reports.

Stanley Qi's bioengineering team at Stanford University started working last year to develop a way to use the CRISPR gene-editing tool to fight influenza, calling their technique "PAC-MAN." It sends a virus-killing enzyme into a virus' RNA — DNA's instructional messenger — that in turn tells the enzyme to attack the virus' genetic material.

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The arrival of the novel coronavirus, with no clear cure or treatment, presented a new opportunity for PAC-MAN. "By scrambling the virus's genetic code, PAC-MAN could neutralize the coronavirus and stop it from replicating inside cells," Science Daily writes.

But there was still the dilemma of how to actually deliver the PAC-MAN technique into lung cells. So after publishing a preprint of their study on the technique, Qi's lab found the Biological Nanostructures Facility at Berkeley Lab's Molecular Foundry. The facility focuses on using lipitoids to deliver therapies, and after a first test, the lipitoids "performed very well" at delivering the gene-scrambling treatment, Science Daily writes. Read more at Science Daily.

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Kathryn Krawczyk

Kathryn is a graduate of Syracuse University, with degrees in magazine journalism and information technology, along with hours to earn another degree after working at SU's independent paper The Daily Orange. She's currently recovering from a horse addiction while living in New York City, and likes to share her extremely dry sense of humor on Twitter.