Science and health experts are bullish on the news about the Pfizer and BioNTech coronavirus vaccine candidate.

The main reason for the excitement is the vaccine looks like it's on pace to fly right past the Food and Drug Administration's 50 percent efficacy threshold, according to its interim analysis, which pegged the rate at 90 percent so far. There's more good news between the lines, though — the companies say they haven't observed any safety concerns among trial volunteers, the immune response should last for up to a year, and it's unlikely any mutations would be able to overcome the immune response.

The analysis looks promising for Pfizer's competitors, as well, since many other candidates are targeting the same protein on the virus. Plus, if the technology behind the vaccine is successful against COVID-19, it could open a realm of possibilities for vaccine development, at large.

That said, there are reasons to temper expectations, which, after all, are based on a press release. The 90 percent efficacy rate could drop as the trial continues (additionally, safety concerns could arise and the questions about immunity length and mutation protection remain open-ended), and there's also a lack of clarity about whether the vaccine may protect against the most severe COVID-19 cases and whether it protects elderly people. Tim O'Donnell

On the last night of his presidency, only a few hours after delivering an enervated farewell address, Donald Trump reminded us why he is one of the most bizarre characters in recent American political life by releasing his final list of pardons.

Trump pardoned some 73 persons on his way out the door and commuted the sentences of 70 others. Some of those on the receiving end of his clemency were famous. Most were not. There are not many lists on which Lil Wayne and Kodak Black will appear alongside Steve Bannon and various disgraced former Republican party officials. I was pleased that Kwame Kilpatrick, the former mayor of Detroit whose sentence of 28 years in prison speaks more to the selective outrage of white suburban housewives in his home state than to the severity of his crimes, will be leaving prison soon.

Many of the comparatively unknown persons were obviously deserving: felons who had served their time honorably and devoted their lives to good works. Others, including the bird killer James E. Johnson, the Israeli spy Aviem Sella, three members of a clan of fraudulent South Dakota beef sellers, and many others guilty of financial crimes, seem more questionable. The strangest addition of all was that of Robert Bowker, who pled guilty three decades ago to the crime of illegally transporting 28 snakes owned by Rudy "Cobra King" Komarek to a reptile house in Miami. It appears that the aforementioned monarch offered Bowker a bribe of exactly 22 alligators, albeit one that he did not accept.

Perhaps even more interesting were those whose names did not appear on the list. Trump did not, as some expected, issue pardons to Republican members of Congress for the non-existent crime of challenging the Electoral College results in a handful of states, nor did he extend them to members of his family. Most important, he did force the interesting constitutional question of a self-pardon, likely because the legal action to which he is most vulnerable will come either from state governments or from the United States Senate, from neither of which a pardon would have shielded him. Matthew Walther

For the first times in weeks, President Trump's official schedule for Wednesday, Jan. 20, does not say "he will make many calls and have many meetings." In fact, it has only one item on it: His departure from the White House for Joint Base Andrews in Maryland, the final official stop of his presidency.

About 45 minutes after Trump's scheduled departure, President-elect Joe Biden, Vice President-elect Kamala Harris, and their spouses will attend church services at the Cathedral of St. Matthew the Apostle, according to Biden's first official presidential schedule. Biden and Harris will be sworn in at noon, then they'll review military forces in a pass in review, lay a wreath at Arlington National Cemetery's Tomb of the Unknown Soldier, and finally head to the White House, where Biden is scheduled to start work at 5:15 p.m.

The Bidens begin their celebrations at 8:48 p.m., for some reason, and their final scheduled event is just before 10 p.m. Peter Weber

President-elect Joe Biden and Vice President-elect Kamala Harris really did create a playlist of 46 songs for Wednesday's inauguration of the 46th president. Stephen Colbert's Late Show made some changes to the playlist Tuesday night. It's "a well-rounded mix of classic hits and in no way a cryptic jab at the outgoing administration" nor "a thinly veiled putdown of the soon-to-be ex-president," The Late Show insists. "These songs were selected on their musical merits, not because when read sequentially, they taunt the man who tried to destroy our democracy."

In the real world, President Trump is "particularly upset that Lady Gaga, Jennifer Lopez, Tom Hanks, and other stars agreed to perform as part of Biden's inaugural celebrations," after Trump's "harsh rhetoric, hard-line immigration policy, and other stances during the 2016 campaign led Hollywood to largely boycott his inauguration," The Washington Post reports. Trump is "a believer in the power of being associated with marquee names," so the snubs apparently stung hard. In comparison, a fake playlist would probably just pinch. Peter Weber

President Trump's last big batch of pardons will get most of the attention, but he also issued an executive order in his last few hours in office that seeks to free all current and former hires from the ethics agreements they signed to work in his administration. Trump revoked his January 2017 "Ethics Commitments by Executive Branch Appointees" order, the White House announced early Wednesday, so "employees and former employees subject to the commitments in Executive Order 13770 will not be subject to those commitments after noon January 20, 2021."

Those commitments included not lobbying the federal agencies they served under for five years after leaving government. The executive order, Yashar Ali notes, was the backbone of Trump's "drain the swamp" pledge.

President-elect Joe Biden takes office at noon on Wednesday, and presumably he could just issue a new executive order reversing Trump's.

Norm Eisen, "ethics czar" to former President Barack Obama, said in a Politico column Tuesday that Obama's clear ethics rules led to "arguably the most scandal-free presidency in memory," but "Trump greatly watered down the standards with scandalous results" and "Biden has done the opposite, restoring the Obama rules and expanding them."

Biden's planned executive order, Eisen wrote, "restores the fundamentals of the Obama plan, closing loopholes Trump opened—but going further, including new crackdowns on special interest influence. If implemented rigorously (always a big if) Biden's plan promises to go further to 'drain the swamp' than either of his predecessors." Peter Weber

President Trump has granted pardons to 73 individuals and commuted an additional 70 sentences, the White House announced early Wednesday morning.

There are several well-known names on the list, including Stephen Bannon, Trump's former chief strategist; Elliott Broidy, a major Trump fundraiser and former deputy national finance chair of the Republican National Committee; rapper Lil Wayne; and former Detroit Mayor Kwame Kilpatrick. Trump also pardoned or commuted the sentences of individuals — including several former members of Congress — convicted of drug offenses, fraud, and lying to federal investigators.

In 2013, Kilpatrick was convicted for his part in a racketeering and bribery scheme conducted while in office; Trump commuted his sentence after Kilpatrick served seven years in prison. The White House said several people — including social media personalities Diamond and Silk and televangelist Paula White — supported this commutation.

Similarly, there were several people pushing Trump to grant Broidy a full pardon — the White House said Broidy had the support of Rep. Devin Nunes (R-Calif.), Rep. Ken Calvert (R-Calif.), and former U.S. Ambassador to Germany Ric Grenell. Broidy pleaded guilty in October to conspiring to violate foreign lobbying laws, and was scheduled to be sentenced in February.

Bannon, however, did not have a long list of supporters. The White House simply said Bannon — who was charged with defrauding investors through a group called "We Build the Wall" — received a full pardon and "has been an important leader in the conservative movement and is known for his political acumen." The organization received donations from Trump fans, something that was not lost on Rep. Adam Schiff (D-Calif.):

Last month, Trump pardoned his former campaign chairman Paul Manafort and longtime friend Roger Stone. He still has a few more hours to issue additional pardons and commutations, but is not expected to do so. Catherine Garcia

President Trump pardoned Stephen Bannon, his 2016 campaign chairman and one-time White House aide, late Tuesday amid a final flurry of executive clemency with just hours left in his administration. Bannon was arrested in August and charged with defrauding investors, mostly Trump supporters, through a group called "We Build the Wall."

In its pardon notice, the White House said Bannon had received "a full pardon" for "charges related to fraud stemming from his involvement in a political project," adding that the former Breitbart News chief "has been an important leader in the conservative movement and is known for his political acumen." Trump has already pardoned another 2016 campaign chairman, Paul Manafort, as well as longtime ally Roger Stone and other 2016 advisers and allies.

The "We Build the Wall" campaign raised more than $25 million, ostensibly to build a border wall between the U.S. and Mexico. Federal prosecutors alleged that Bannon siphoned off more than $1 million through a nonprofit he controlled and gave hundreds of thousands of dollars to another organizer, Brian Kolfage, who was also charged in the alleged scheme. Kolfage was not on Trump's pardon list. Trump distanced himself from Bannon and the fundraising project after the arrests, and aides believed Bannon was not going to get a pardon up until Tuesday, CNN reports.

Trump "made the decision on Mr. Bannon after a day of frantic efforts to sway his thinking, including from Mr. Bannon himself, who spoke to him by phone on Tuesday," The New York Times reports. After Bannon helped elect Trump and joined his White House, the two had a dramatic falling-out when Bannon told journalist Michael Wolff, for his book Fire and Fury, that Ivanka Trump is "dumb as a brick" and Donald Trump Jr. had acted "treasonous" by meeting with Russian agents during the campaign. But since last summer, "Bannon has slowly come back into the Trump orbit," The Washington Post notes.

Bannon may still be in legal jeopardy for his work with exiled Chinese billionaire Guo Wengui, and state prosecutors might still be able to charge him for any "We Build the Wall" fraud. Peter Weber