Creating almost-life in the lab

It isn't alive, but feeds, grows, and replicates much like it is

SpudCells, shown in a composite image based on microscopy, mimic key cellular functions.
A super-resolution image of SpudCell’s liposomes with an encapsulated genome and active protein expression. SpudCell is the first synthetic cell system built from non-living components to complete a full cell cycle.
(Image credit: Orion Venero, Adamala Lab)

Scientists have assembled a cell from scratch in the laboratory for the first time — one that feeds, grows, and replicates much as a natural cell does.

Synthetic biologist Kate Adamala and her team at the University of Minnesota built the prototype molecule by molecule from nonliving chemicals, reports New Scientist. It turned out looking rather like a potato, so they nicknamed it SpudCell. SpudCell is similar to a simple bacterium, but it’s made of just 150 to 200 molecules, while a biological cell holds millions or billions. It was assembled using 36 genes, including some from E. coli bacteria, some from phage viruses, and one from jellyfish: a fluorescent protein that helps make the cell visible. That it can replicate itself makes it lifelike, but its autonomy is limited.

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