If one company has its way, animal allergies could soon be a thing of the past. A biotech laboratory has developed gene-edited dogs that do not contain the allergy-causing proteins found in most pups, which they say marks a major breakthrough in the pet industry. But it could still be a long time before dogs like these become available on a wide scale.
How were these dogs created?
Bailey and Alfie are two beagles who were specifically bred with a “targeted genetic knockout” of Can f 1, the major allergy-causing protein in dogs, according to research published in The CRISPR Journal. The canines were born in September 2024 and “have shown healthy growth and development,” Kindred Companion Sciences, the company behind the research, said in a press release.
The idea of allergy-friendly dogs is not new, and breeds like poodles are often recommended for their hypoallergenic coats. But these dogs “still produce allergy-causing proteins that end up in their saliva, hair and dander, so they can still make people sniffly,” said The Associated Press. In the case of Bailey and Alfie, scientists at Kindred used the DNA-altering technology CRISPR to eliminate the Can f 1 protein entirely. Tests of the two dogs thus “showed no detectable protein compared to samples from non-edited dogs,” said Wired.
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The use of genetic editing to create completely hypoallergenic dogs marks a significant shift in the field. Previously, efforts to “reduce dog allergen exposure have focused on downstream mitigation, including selection of so-called ‘hypoallergenic’ breeds and household hygiene measures,” said The CRISPR Journal. But scientists have started looking into new approaches, as tests measuring Can f 1 “have found that breeds marketed as hypoallergenic do not yield consistently lower environmental exposure.”
How will this affect the pet industry?
Experts believe it could open the door to a new wave of adoptable pets. Gene editing “can, and should, be applied to solving legitimate problems that humanity has,” Fyodor Urnov, a gene editing expert at the University of California, Berkeley, said to Wired. “Dogs are a human’s best friend, now potentially more so because of one tiny gene edit.”
Questions remain as to the viability of the genetic changes. For one, Can f 1 “isn’t the only protein in dogs that can trigger allergic reactions — there are also so-called minor allergens,” said New Scientist. There are also concerns about the long-term health of these dogs, although “so far, both dogs appear normal and healthy.” Researchers overall maintain that this option could be groundbreaking for people with pet allergies, which is about 10 to 20% of the world’s population, according to the Asthma and Allergy Foundation of America.
“The feeling right now is sort of a mix of relief and awe and gratitude that it worked,” geneticist Matt Walker, the founder of Kindred, said to the AP. “It feels just amazing to get to have a dog.” For others, the jury is still out. “It opens the door to a lot more people being able to own pets,” New York University bioethicist Arthur Caplan told the AP. But on the “negative side, it may discourage people from trying to use strays and unwanted animals that are not engineered to be allergy-free.”
