Alzheimer's disease is an illness of the brain that causes memory loss and other losses in cognitive function, as well as being responsible for over half of all dementia cases. Because there isn't a cure or treatment that can reverse the deterioration of mental function due to Alzheimer's, prevention is often people's best hope of not getting the disease. And now, researchers at the University of New Mexico are working on a preventative treatment in an unlikely form: a vaccine.
While usually vaccines target illnesses that are caused by invasive microorganisms like bacteria and viruses, this one actually targets a protein that is often found in the brains of Alzheimer's patients, reported KRQE, an affiliate of CBS. The protein, called "pathological tau," was successfully cleared by the antibodies in the vaccine when tested on mice with Alzheimer's.
To test the effectiveness of pathological tau's removal, the researchers put the mice through a series of "maze-like tests," in which the mice that received the vaccine did reliably better than those that didn't. But of course, there's still a long road between testing a vaccine on mice and getting it ready for humans.
The researchers, Kiran Bhaskar and Nicole Maphis, still need to secure funding in order to create a vaccine that could be tested in humans. And once that's complete, the FDA approval process could take an additional 5 years. But they're still pleased with the results of their initial study: "I really wanted to take this as a challenge," said Bhaskar, who has been working towards an Alzheimer's cure since 2013.
Read more at KRQE. Shivani Ishwar
Jojo Rabbit just earned a key victory in the 2020 Oscars race.
The dramedy from director Taika Waititi won the People's Choice Award at the Toronto International Film Festival Sunday, the prize that in the past has typically gone to movies that went on to become Best Picture nominees or winners at the Academy Awards.
In fact, since 2009, the TIFF People's Choice Award winner was ultimately nominated for Best Picture nine out of ten times, and it won Best Picture three times.
One of those instances was last year, when Green Book picked up the TIFF People's Choice Award in what was, in retrospect, the first major sign of its eventual Best Picture triumph. Best Picture winners 12 Years a Slave and The King's Speech also previously won the TIFF award, which is voted on by audiences at the festival.
Jojo Rabbit wasn't as well received by critics as other TIFF films like Ford v Ferrari and Marriage Story, though. Dubbed an "anti-hate satire," the movie features Waititi playing an imaginary version of Adolf Hitler, and it currently holds a 75 percent approval rating on Rotten Tomatoes, with the consensus noting its "blend of irreverent humor and serious ideas definitely won't be to everyone's taste."
The runners up for the TIFF People's Choice Award were Marriage Story and Parasite, both of which are strong contenders to become Best Picture nominees, although runners up for the audience award don't always score nominations. Of last year's runners up, one, Roma, was nominated for Best Picture, while the other, If Beale Street Could Talk, was not.
Jojo Rabbit, which also stars Scarlett Johansson, Sam Rockwell, Rebel Wilson, and Alfie Allen, hits theaters on Oct. 18. Brendan Morrow
After shaking off the Week 1 cobb-webs, the NFL season is in full swing. Here are four Week 2 games to watch Sunday:
Miami Dolphins vs. New England Patriots, 1 p.m. on CBS — This game will likely be ugly, seeing as it pits the defending Super Bowl champion Patriots against the Dolphins, who are in full rebuild mode. But it is also expected to be Antonio Brown's first game in the New England uniform. While Brown is one of the league's most exciting players on the field, he's also one of its most controversial. After a tumultuous offseason, the wide receiver is now facing sexual assault allegations.
Tennessee Titans vs. Indianapolis Colts, 1 p.m. on CBS — The Titans were one of the league's most impressive teams in Week 1, after demolishing the trendy Cleveland Browns, 43-13. This divisional showdown should shed some more light on just how good Tennessee really is. The Colts, meanwhile, are coming off a close loss the Los Angeles Chargers, but it seems like they should remain competitive even without recently-retired quarterback Andrew Luck.
Baltimore Ravens vs. Arizona Cardinals, 1 p.m. on Fox — This one is all about the quarterbacks. Baltimore's Lamar Jackson was dominant against a paltry Miami defense last week — five touchdowns and a perfect passer rating are impressive no matter who the opponent is. Kyler Murray, the no. 1 pick in this year's draft, will be under center for Arizona. Murray struggled early in his debut against the Detroit Lions, but he went on to lead a comeback that ended in a tie.
Los Angeles Rams vs. New Orleans Saints, 4:25 p.m. on Fox — New Orleans fans have been waiting for this one. The two teams met in last year's NFC championship game where it looked like New Orleans was going to the Super Bowl. But a bizarre no-call on a play that most agree should have been defensive pass interference on the Rams allowed Los Angeles enough time to force overtime and, eventually, win. Tim O'Donnell
The United Auto Workers said its roughly 49,000 members who work at General Motors plants across the country will strike beginning at 11:59 p.m. Sunday evening.
A four-year contract between GM and the union expired Saturday and the two sides failed to reach a new agreement as talks broke down. GM said Sunday the auto company's offer to the union includes more than $7 billion in investments, more than 5,400 jobs, higher pay, and improved benefits.
"We have negotiated in good faith and with a sense of urgency," the automaker said in a statement. "Our goal remains to build a strong future for our employees and our business."
But union leaders said the sides are far apart on economic issues, despite some progress being made in the negotiation. "We are standing up for job security for our members and their families," Terry Dittes, director of the UAW GM department, said. He added that the the strike "represents great sacrifice and great courage on the part of our members."
The last time a national strike was called was 2007. It lasted for 17 hours. Read more at The Associated Press and The Detroit News. Tim O'Donnell
Max Stier, a former Yale University classmate of Supreme Court Justice Brett Kavanaugh, reportedly notified senators and the FBI during the justice's confirmation process last year about a previously unreported sexual misconduct allegation involving Kavanaugh when he was a student at Yale.
Stier reportedly said he saw Kavanaugh — a freshman at the time — at a drunken dorm party with his pants down when his friends then pushed his penis into a female student's hands. The story is similar to an allegation against Kavanaugh made by another Yale student, Deborah Ramirez, but it is unclear if they are the same incident. It is also unclear if Stier knew the female student, or if she has verified the incident as described.
The FBI reportedly did not investigate the allegation and Stier has declined to speak about it publicly, but The New York Times reports it corroborated the story with two officials who have communicated with Stier.
Kavanaugh faced multiple allegations of sexual misconduct during his confirmation process, though only one of his accusers, Christine Blasey Ford, was permitted to testify to the Senate Judiciary Committee last year. Kavanaugh has denied the allegations. Read more at The New York Times. Tim O'Donnell