The coronavirus appears to have "one big trick," Shane Crotty, a professor in the Center for Infectious Disease and Vaccine Research at the La Jolla Institute for Immunology, told Bloomberg.
That trick — avoiding the human body's "initial innate immune response for a significant period of time," and, particularly, the response of a substance called interferon that typically helps orchestrate the defense against viral pathogens — is linked to more severe cases. Indeed, new studies published last week in Science found that an insufficient amount of interferon, the production of which may sometimes be inhibited in people with previously "silent" gene mutations and other times is actually disabled by a person's immune response, could signal a more dangerous infection.
The good news is that, because scientists are catching on to the virus' strategy, they have a better idea of how to prevent it from causing severe infections. Writes Bloomberg, the work highlights the potential for interferon-based therapies, which are typically used in in the early stages of a viral infection when it's easier to avoid life-threatening respiratory failure. Now, dozens of studies focusing on interferon treatments are recruiting COVID-19 patients. Read more at Bloomberg.
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