Screenshot/YouTube/The Late Show

The COVID-19 vaccine is open to all Americans 16 and older as of Monday, and "the Biden administration is trying to get the word out," Jimmy Fallon said on Monday's Tonight Show, skeptically. "Your idea to get kids vaccinated is putting an 80-year-old scientist on TikTok? Good luck with that. You know Biden's old when he's like, 'We need someone young and hip for the Snapchat videos. How about that kid Dr. Fauci?'"

NASA successfully flew a helicopter on Mars, Fallon noted. "The flight lasted a total of 30 seconds. The men on the team said it was a complete success, while the women agreed so they wouldn't hurt anyone's feelings." And "a new poll shows Matthew McConaughey is leading Gov. Greg Abbott by 12 points in a hypothetical matchup for governor of Texas," he said. "When asked if he's actually gonna run for office, McConaughey said 'I might, I might, I might.'"

The Late Show created a clearly unsolicited campaign commercial for McConaughey.

One highlight of Sunday night's star-studded COVID-19 special, featuring Biden and and Barack Obama, was "when Dr. Anthony Fauci was interviewed by actor Matthew McConaughey," Stephen Colbert said on The Late Show. "Wow, the sexiest man alive was interviewed by Matthew McConaughey!" For anyone wondering, he added, "I can say categorically that Matthew McConaughey is not going to run for governor. He's going to drive a Lincoln, talking to himself the entire time."

Colbert made extended, elaborate Anglo-Saxon jokes to mock Rep. Marjorie Taylor Greene's (R-Ga.) short-lived America First Caucus, including a Beowulf zinger.

"President Biden over the weekend attended the confirmation of his grandson," Late Night's Seth Meyer said, "but then Mitch McConnell said it's too close to an election and put all confirmations on hold."

Jimmy Kimmel spent most of his monologue in a mutual fascination loop with MyPillow chief Mike Lindell, but he also had some ideas for promoting COVID-19 vaccines to the Republican and white evangelical men opposed to getting inoculated. "I don't think a TV special or putting Dr. Fauci on Snapchat is going to do anything to convince people, these men who don't want to get the shot," he said. "There's a lot of disinformation out there, and I think the CDC should just stop trying to appeal to common sense and embrace the nonsense." Watch Kimmel Live's PSA below. Peter Weber