Shingles vaccine cuts dementia risk, study finds

'We don’t really have much else at the moment that slows down the onset of dementia'

(Image credit: Cavan Images via Getty Images)

published 3 April 2025

What happened

Getting vaccinated against shingles appears to significantly reduce the chances of developing Alzheimer's and other forms of dementia, according to a study published Wednesday in the journal Nature. The study, based on the health records of 280,000 people in Wales, found that those who received an older live-virus vaccine, Zostavax, were 20% less likely to develop dementia within seven years than those not vaccinated.

Previous research suggested that "shingles vaccinations might reduce dementia risk," including a 2024 study that found even greater protection from the newer vaccine Shingrix, The New York Times said. But the latest study overcame limitations in earlier observational data by taking advantage of a "natural experiment" in Wales, where health officials allowed 79-year-olds to get vaccinated but not 80-year-olds, effectively creating a randomized trial among two groups born weeks apart.

A 20% dementia reduction from the shingles vaccine would be "quite important," especially as "we don’t really have much else at the moment that slows down the onset of dementia," Oxford researcher Dr. Paul Harrison, who wasn't involved in this study, told the Times. People should get vaccinated regardless, Dr. Aarati Didwania of Northwestern University said to NBC News. "Shingles is a terrible, painful and debilitating condition that can lead to horrendous long-term pain."

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Peter has worked as a news and culture writer and editor at The Week since the site's launch in 2008. He covers politics, world affairs, religion and cultural currents. His journalism career began as a copy editor at a financial newswire and has included editorial positions at The New York Times Magazine, Facts on File, and Oregon State University.