April 11, 2014

Like scaffolding that props up a building, scientists are now using temporary frameworks to create custom-designed, complex new organs, which they've successfully implanted in several patients. These breakthroughs were revealed in two extraordinary studies on the engineering of body parts published Thursday in The Lancet.

Here's the basics of how the process works: Doctors first extract cells from a patient's muscle and tissue, then use those cells to seed 3-D biodegradable scaffolding of the target organ that they've constructed from scans of the patient's body. After a few weeks in an incubator, the seed cells have spread across the scaffolding to produce a layer of tissue, and the new organ is implanted in the patient. The scaffolding is absorbed into the body as the cells continue to grow.

One team worked on creating nasal cartilage, while another grew new vaginas. "This is a move forward to even more challenging [organs]," Ian Martin, a professor of tissue engineering at University Hospital Basel in Switzerland and co-author of the nasal cartilage study, told CNN. "All these incremental steps finally have demonstrated that it is possible to engineer tissue that can help patients."

The reproductive organ study involves four teenagers born with a rare condition called Mayer-Rokitansky-Küster-Hauser Syndrome. The women were all born either without or with a deformed uterus or vagina. According to CNN, after receiving their new sex organs, the patients all indicated that they had "normal levels of desire, arousal, lubrication, orgasm, satisfaction, and painless intercourse." Two of the patients now also menstruate.

The patients in the nasal tissue study were all elderly and had recently undergone cancer surgery. Ordinarily, doctors reconstruct noses with big pieces of cartilage taken from the ear, septum, or ribs — a very painful process. This time, scientists removed a tiny piece of tissue from each patient's nasal septum — roughly half the size of the tip of a pen — and put it onto a scaffold. The cells formed a thin layer of cartilage that was then transplanted to the patient.

Scientists hope that these amazing findings will help more people in the future, including those who need replacement cartilage or whose reproductive systems have been damaged. "Tissue engineering is finally demonstrating that it can deliver on expectations," Martin said. Catherine Garcia

8:41 p.m. ET

Fans of the Denver Broncos and Carolina Panthers went all out for Super Bowl 50, donning their wackiest wigs, outfits, and accessories for the big game (all in shades of orange and blue, of course), with some even going so far as shaving the number of their favorite player into their hair. Here's a look at some of the biggest fans at Levi's Stadium. Catherine Garcia

8:18 p.m. ET

Jordan Norwood of the Denver Broncos set a record on Sunday for the longest punt return in Super Bowl history.

Norwood caught the ball and sprinted for 61 yards before being ran down by Mario Addison on the Panthers' 14-yard-line, NBC Sports reports. The new record shatters the previous one made by John Taylor, 45 yards, during Super Bowl XXIII. Catherine Garcia

8:00 p.m. ET

Carolina Panthers quarterback Cam Newton is known to celebrate first downs and touchdowns by "dabbing," but did you know it was actually Betty White who taught him everything he knows about the dance craze? Okay, that might not be entirely true, but White is certainly taking credit for it in a new CBS Sports video. Watch everyone's favorite golden girl show off her moves in the video below. Catherine Garcia

7:31 p.m. ET

Before Super Bowl 50 began, the MVPs from previous years were celebrated during a ceremony at Levi's Stadium.

Former football stars Joe Montana, Joe Namath, Jerry Rice, Steve Young, and Ray Lewis were cheered, but one player wasn't shown the same respect — Patriots quarterback Tom Brady, who instead was booed by the crowd. Watch the video below. Catherine Garcia

6:50 p.m. ET

Super Bowl 50 started off with a bang, as Lady Gaga sang a beautiful rendition of the National Anthem. In an earlier interview with the NFL Network, the pop star said performing at the Super Bowl was an "honor" and "a total dream come true." Catherine Garcia

6:37 p.m. ET
Al Bello/Getty Images

Peyton Manning and the Denver Broncos are facing off against Cam Newton and the Carolina Panthers in Super Bowl 50, and those who don't have access to a television can still watch every minute of the game during the livestream on

2:19 p.m. ET

Larry David and Bernie Sanders appeared alongside each other on Saturday Night Live, but the real highlight of the night didn't involve Sanders at all. In this pre-taped sketch, watch David play a cranky, neurotic Sanders in the cleverly titled "Bern Your Enthusiasm." Julie Kliegman

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