Cancer ‘vaccine’ to enter human trials
Single injection caused immune system to obliterate tumours in trials on mice
A revolutionary cancer vaccine that can eliminate tumours even after they have spread throughout the body is to go into human trials.
The move follows trials on mice in which the treatment worked “startlingly well”, according to researchers, with 90% of the animals cured after one injection, and the rest after a second jab.
The team at Stanford University, in California, say that “injecting tiny amounts of two drugs directly into a tumour not only kills the original cancer, but also triggers an ‘amazing bodywide’ reaction which destroys distant cancer cells”, reports The Daily Telegraph.
Subscribe to The Week
Escape your echo chamber. Get the facts behind the news, plus analysis from multiple perspectives.
Sign up for The Week's Free Newsletters
From our morning news briefing to a weekly Good News Newsletter, get the best of The Week delivered directly to your inbox.
From our morning news briefing to a weekly Good News Newsletter, get the best of The Week delivered directly to your inbox.
The drug combination works by “switching on immune cells inside the tumours which have been deactivated by the cancer, then boosting them so they can go to work killing the disease”, the newspaper adds.
“When we use these two agents together, we see the elimination of tumours all over the body,” said Professor Ronald Levy, who led the study.
“This approach bypasses the need to identify tumour-specific immune targets and doesn’t require wholesale activation of the immune system or customisation of a patient’s immune cells.”
For the human trial, “Levy plans to recruit 15 patients with low-grade lymphoma”, says the Daily Mail. “If successful, Levy believes the treatment could be useful for many tumour types.”
In the future, he believes oncologists “could inject both [agents] into solid tumours in humans before surgery as a way to prevent recurrence from stray tumours that spread but weren’t detected”, according to the newpaper.
“I don’t think there’s a limit to the type of tumour we could potentially treat, as long as it has been infiltrated by the immune system,” Levy said.
Levy and his team “deserve a lot of credit” for testing the combined treatment on a strain of mouse that is prone to spontaneously develop breast tumours - which mimics how cancer arises in humans, immunologist Drew Pardoll, of the Bloomberg-Kimmel Institute for Cancer Immunotherapy in Baltimore, Maryland, told Science magazine.
But “the big question is whether the approach works in people, as most rodent cancer therapies don’t translate to humans”, the magazine notes.
Sign up for Today's Best Articles in your inbox
A free daily email with the biggest news stories of the day – and the best features from TheWeek.com
-
The week's best photos
In Pictures Firing shells, burning ballots, and more
By Anahi Valenzuela, The Week US Published
-
The Great Mughals: a 'treasure trove' of an exhibition
The Week Recommends The V&A's new show is 'spell-binding'
By The Week UK Published
-
Damian Barr shares his favourite books
The Week Recommends The writer and broadcaster picks works by Alice Walker, Elif Shafak and others
By The Week UK Published
-
Home Office worker accused of spiking mistress’s drink with abortion drug
Speed Read Darren Burke had failed to convince his girlfriend to terminate pregnancy
By The Week Staff Published
-
In hock to Moscow: exploring Germany’s woeful energy policy
Speed Read Don’t expect Berlin to wean itself off Russian gas any time soon
By The Week Staff Published
-
Were Covid restrictions dropped too soon?
Speed Read ‘Living with Covid’ is already proving problematic – just look at the travel chaos this week
By The Week Staff Last updated
-
Inclusive Britain: a new strategy for tackling racism in the UK
Speed Read Government has revealed action plan setting out 74 steps that ministers will take
By The Week Staff Published
-
Sandy Hook families vs. Remington: a small victory over the gunmakers
Speed Read Last week the families settled a lawsuit for $73m against the manufacturer
By The Week Staff Published
-
Farmers vs. walkers: the battle over ‘Britain’s green and pleasant land’
Speed Read Updated Countryside Code tells farmers: ‘be nice, say hello, share the space’
By The Week Staff Published
-
Motherhood: why are we putting it off?
Speed Read Stats show around 50% of women in England and Wales now don’t have children by 30
By The Week Staff Published
-
Anti-Semitism in America: a case of double standards?
Speed Read Officials were strikingly reluctant to link Texas synagogue attack to anti-Semitism
By The Week Staff Published