Health & Science

A clue to the cause of Alzheimer’s; The growing coral-reef crisis; A dark-matter discovery; How pets benefit babies

A clue to the cause of Alzheimer’s

A rare gene mutation that protects people from getting Alzheimer’s could help steer researchers toward drugs that slow the disease’s devastating progress. Icelandic researchers tested 1,795 Icelanders and found that about 1 percent of them have a genetic variation that slows the formation of the protein beta amyloid, which is known to build up as plaque in the brains of Alzheimer’s patients. People with the mutation have 40 percent less beta amyloid in their brains and are 81 percent less likely to develop Alzheimer’s after age 85 than those without the mutation, the study found. “It confers extraordinarily strong protection,” neurologist Kari Stefansson tells Reuters.com. There’s little point in testing for the protective variation, which is thought to be present in only 1 in 10,000 North Americans. The finding’s real importance is that it shows a crucial link between beta amyloid formation and Alzheimer’s, offering encouragement for efforts to develop drugs aimed at stopping the gummy plaque from forming, in the hope of preventing or slowing the onset of the disease. “This provides some of the strongest evidence ever that amyloid is the right target in Alzheimer’s,” said researcher Sam Gandy of Mount Sinai School of Medicine in New York.

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